ID Q684L2_9HEXA Unreviewed; 472 AA.
AC Q684L2;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=protein-synthesizing GTPase {ECO:0000256|ARBA:ARBA00011986};
DE EC=3.6.5.3 {ECO:0000256|ARBA:ARBA00011986};
GN Name=eIF2g {ECO:0000313|EMBL:CAG29667.1};
OS Allacma fusca.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Symphypleona; Sminthuridae; Allacma.
OX NCBI_TaxID=39272 {ECO:0000313|EMBL:CAG29667.1};
RN [1] {ECO:0000313|EMBL:CAG29667.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15356279; DOI=10.1093/molbev/msh255;
RA Krauss V., Pecyna M., Kurz K., Sass H.;
RT "Phylogenetic mapping of intron positions: a case study of translation
RT initiation factor eIF2gamma.";
RL Mol. Biol. Evol. 22:74-84(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001874};
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DR EMBL; AJ715861; CAG29667.1; -; Genomic_DNA.
DR AlphaFoldDB; Q684L2; -.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR CDD; cd01888; eIF2_gamma; 1.
DR CDD; cd03688; eIF2_gamma_II; 1.
DR CDD; cd15490; eIF2_gamma_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015256; eIF2g_C.
DR InterPro; IPR044127; eIF2g_dom_2.
DR InterPro; IPR044128; eIF2g_GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF09173; eIF2_C; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:CAG29667.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 39..247
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 472 AA; 51432 MW; FC8E336E5C3CB2F3 CRC64;
MSGDVANKPM GQPHLAKQDL ATLDVNKLTP LSPEVISRQA TINIGTIGHV AHGKSTVVKA
ISGVQTVRFK NELERNITIK LGYANAKIFK CDNEKCPRPT CYISGGSSKD DSFPCFSGTC
QGRFRLIRHV SFVDCPGHDI LMATMLNGAA VMDAALLLIA GNESCPQPQT SEHLAAIEIM
KLKHIIILQN KIDLVKENQA KEQYDQIIKF VQGTVAEGAP VIPISAQLKY NIEVLCEYVT
KKIPISIRDF TSEPRLIIIR SFDVNKPGSE VEDLKGGVAG GSILKGVLKV GQEIEVRPGL
VSKDSEGRLH CRPIFSRIVS LYAEQNDLQY AVPGGLIGVG TLIDPTLCRA DRMVGQVLGS
VGALPEIYIE IEISYYLLRR LLGVRTEGDK KAAKVQKLSK GEVLMVNIGS LSTGGRVTAV
KADLAKVALT NPVCTEIGEK IALSRRVEKH WRLIGWGQIR RGVTITPEAR RD
//
