GenomeNet

Database: UniProt
Entry: Q68DX3
LinkDB: Q68DX3
Original site: Q68DX3 
ID   FRPD2_HUMAN             Reviewed;        1309 AA.
AC   Q68DX3; B7WNW0; B7ZML5; Q2VY07; Q6GMQ9; Q6ZN38; Q6ZWI2; Q8N5T9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 3.
DT   29-OCT-2014, entry version 103.
DE   RecName: Full=FERM and PDZ domain-containing protein 2;
DE   AltName: Full=PDZ domain-containing protein 4;
DE   AltName: Full=PDZ domain-containing protein 5C;
GN   Name=FRMPD2; Synonyms=PDZD5C, PDZK4, PDZK5C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
RA   Xu J., Xie Y., Mao Y.;
RT   "Identification of a novel PDZ domain-containing gene.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND
RP   VARIANTS GLU-534 AND LYS-1021.
RC   TISSUE=Hippocampus, and Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP   LYS-1021.
RC   TISSUE=Retina;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   FUNCTION, INTERACTION WITH ARVCF; CTNND2 AND PKP4, MUTAGENESIS OF
RP   LYS-955, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=19706687; DOI=10.1242/jcs.046854;
RA   Stenzel N., Fetzer C.P., Heumann R., Erdmann K.S.;
RT   "PDZ-domain-directed basolateral targeting of the peripheral membrane
RT   protein FRMPD2 in epithelial cells.";
RL   J. Cell Sci. 122:3374-3384(2009).
RN   [7]
RP   VARIANT [LARGE SCALE ANALYSIS] TRP-727.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May play a role in the regulation of tight junction
CC       formation. Binds phosphatidylinositol 3,4-bisphosphate
CC       (PtdIns(3,4)P2). {ECO:0000269|PubMed:19706687}.
CC   -!- SUBUNIT: Interacts (via the PDZ 2 domain) with CTNND2 (via the
CC       extreme C-terminus). Interacts (via the PDZ 2 domain) with PKP4
CC       (via the extreme C-terminus); this interaction directed FRMPD2 to
CC       the basolateral membranes. Interacts (via the PDZ 2 domain) with
CC       ARVCF (via the extreme C-terminus). {ECO:0000269|PubMed:19706687}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Basolateral cell
CC       membrane {ECO:0000269|PubMed:19706687}. Cell junction, tight
CC       junction {ECO:0000269|PubMed:19706687}. Note=Colocalizes with
CC       CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes
CC       with TJP1 at tight junctions. Its recruitment to cell-cell
CC       contacts requires CDH1.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1;
CC         IsoId=Q68DX3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q68DX3-2; Sequence=VSP_028523, VSP_028524, VSP_028527;
CC         Note=No experimental confirmation available.;
CC       Name=3;
CC         IsoId=Q68DX3-3; Sequence=VSP_028525, VSP_028526;
CC         Note=No experimental confirmation available.;
CC       Name=4;
CC         IsoId=Q68DX3-4; Sequence=VSP_028522, VSP_028528;
CC       Name=5;
CC         IsoId=Q68DX3-5; Sequence=VSP_028521;
CC   -!- TISSUE SPECIFICITY: Expressed in epithelial cells.
CC       {ECO:0000269|PubMed:19706687}.
CC   -!- DOMAIN: The FERM and PDZ 2 domains are necessary for localization
CC       to the basolateral cell membrane. The FERM domain binds to
CC       phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and is
CC       sufficient for membrane localization.
CC   -!- SIMILARITY: Contains 1 FERM domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00084}.
CC   -!- SIMILARITY: Contains 1 KIND domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00709}.
CC   -!- SIMILARITY: Contains 3 PDZ (DHR) domains. {ECO:0000255|PROSITE-
CC       ProRule:PRU00143}.
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DR   EMBL; AY491519; AAS79660.1; -; mRNA.
DR   EMBL; AK123038; BAC85520.1; -; mRNA.
DR   EMBL; AK131386; BAD18537.1; -; mRNA.
DR   EMBL; CR749241; CAH18097.1; -; mRNA.
DR   EMBL; AC013284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC074325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC031614; AAH31614.1; -; mRNA.
DR   EMBL; BC073954; AAH73954.1; -; mRNA.
DR   EMBL; BC144635; AAI44636.1; -; mRNA.
DR   EMBL; BC144639; AAI44640.1; -; mRNA.
DR   CCDS; CCDS31195.1; -. [Q68DX3-1]
DR   RefSeq; NP_001018081.3; NM_001018071.3.
DR   RefSeq; NP_001035977.2; NM_001042512.2.
DR   UniGene; Hs.664786; -.
DR   UniGene; Hs.709611; -.
DR   ProteinModelPortal; Q68DX3; -.
DR   SMR; Q68DX3; 371-637, 774-857, 917-1166.
DR   BioGrid; 126788; 2.
DR   STRING; 9606.ENSP00000363317; -.
DR   PhosphoSite; Q68DX3; -.
DR   DMDM; 334302902; -.
DR   PaxDb; Q68DX3; -.
DR   PRIDE; Q68DX3; -.
DR   DNASU; 143162; -.
DR   Ensembl; ENST00000305531; ENSP00000307079; ENSG00000170324. [Q68DX3-2]
DR   Ensembl; ENST00000374201; ENSP00000363317; ENSG00000170324. [Q68DX3-1]
DR   Ensembl; ENST00000474573; ENSP00000422446; ENSG00000170324. [Q68DX3-5]
DR   GeneID; 143162; -.
DR   KEGG; hsa:143162; -.
DR   UCSC; uc001jgg.3; human. [Q68DX3-5]
DR   UCSC; uc001jgi.3; human. [Q68DX3-1]
DR   CTD; 143162; -.
DR   GeneCards; GC10M049364; -.
DR   H-InvDB; HIX0008804; -.
DR   H-InvDB; HIX0035409; -.
DR   H-InvDB; HIX0035410; -.
DR   HGNC; HGNC:28572; FRMPD2.
DR   HPA; HPA045059; -.
DR   MIM; 613323; gene.
DR   neXtProt; NX_Q68DX3; -.
DR   PharmGKB; PA134947461; -.
DR   eggNOG; NOG323402; -.
DR   GeneTree; ENSGT00760000119210; -.
DR   HOVERGEN; HBG105760; -.
DR   InParanoid; Q68DX3; -.
DR   OMA; GFVINEG; -.
DR   OrthoDB; EOG7K9K22; -.
DR   PhylomeDB; Q68DX3; -.
DR   TreeFam; TF315388; -.
DR   GenomeRNAi; 143162; -.
DR   NextBio; 84654; -.
DR   PRO; PR:Q68DX3; -.
DR   Bgee; Q68DX3; -.
DR   CleanEx; HS_FRMPD2; -.
DR   ExpressionAtlas; Q68DX3; baseline.
DR   Genevestigator; Q68DX3; -.
DR   GO; GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0005923; C:tight junction; IDA:UniProtKB.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.
DR   GO; GO:0070830; P:tight junction assembly; IMP:UniProtKB.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR019750; Band_41_fam.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011019; KIND.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR011993; PH_like_dom.
DR   InterPro; IPR029071; Ubiquitin-rel_dom.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   PRINTS; PR00935; BAND41.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00750; KIND; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS51377; KIND; 1.
DR   PROSITE; PS50106; PDZ; 3.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell junction; Cell membrane; Complete proteome;
KW   Cytoplasm; Membrane; Polymorphism; Reference proteome; Repeat;
KW   Tight junction.
FT   CHAIN         1   1309       FERM and PDZ domain-containing protein 2.
FT                                /FTId=PRO_0000306854.
FT   DOMAIN       15    197       KIND. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00709}.
FT   DOMAIN      342    642       FERM. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00084}.
FT   DOMAIN      775    861       PDZ 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00143}.
FT   DOMAIN      950   1035       PDZ 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00143}.
FT   DOMAIN     1079   1167       PDZ 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00143}.
FT   VAR_SEQ       1   1048       Missing (in isoform 5).
FT                                {ECO:0000303|PubMed:15489334,
FT                                ECO:0000303|Ref.1}.
FT                                /FTId=VSP_028521.
FT   VAR_SEQ       1    989       Missing (in isoform 4).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_028522.
FT   VAR_SEQ       1      8       MQPLTKDA -> MHVFIV (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_028523.
FT   VAR_SEQ     103    124       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_028524.
FT   VAR_SEQ     391    392       KE -> GE (in isoform 3).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_028525.
FT   VAR_SEQ     393   1309       Missing (in isoform 3).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_028526.
FT   VAR_SEQ     486    486       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_028527.
FT   VAR_SEQ     990    996       KEGQILQ -> MTSIPFP (in isoform 4).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_028528.
FT   VARIANT      20     20       A -> T (in dbSNP:rs11101272).
FT                                /FTId=VAR_055540.
FT   VARIANT     239    239       T -> M (in dbSNP:rs55802136).
FT                                /FTId=VAR_061034.
FT   VARIANT     534    534       K -> E (in dbSNP:rs1864345).
FT                                {ECO:0000269|PubMed:14702039}.
FT                                /FTId=VAR_055541.
FT   VARIANT     727    727       R -> W (in a colorectal cancer sample;
FT                                somatic mutation).
FT                                {ECO:0000269|PubMed:16959974}.
FT                                /FTId=VAR_035446.
FT   VARIANT    1021   1021       T -> K (in dbSNP:rs1898784).
FT                                {ECO:0000269|PubMed:14702039,
FT                                ECO:0000269|PubMed:17974005}.
FT                                /FTId=VAR_065253.
FT   MUTAGEN     955    955       K->E: Abolishes the basolateral membrane
FT                                localization.
FT                                {ECO:0000269|PubMed:19706687}.
FT   CONFLICT    601    601       K -> E (in Ref. 3; CAH18097).
FT                                {ECO:0000305}.
FT   CONFLICT    624    624       S -> G (in Ref. 3; CAH18097).
FT                                {ECO:0000305}.
FT   CONFLICT    826    826       I -> T (in Ref. 3; CAH18097).
FT                                {ECO:0000305}.
FT   CONFLICT    874    874       S -> G (in Ref. 2; BAC85520).
FT                                {ECO:0000305}.
FT   CONFLICT    895    895       L -> S (in Ref. 2; BAC85520).
FT                                {ECO:0000305}.
FT   CONFLICT    969    969       N -> M (in Ref. 5; AAH73954/AAI44636/
FT                                AAI44640). {ECO:0000305}.
FT   CONFLICT   1077   1077       K -> N (in Ref. 1; AAS79660).
FT                                {ECO:0000305}.
FT   CONFLICT   1174   1174       L -> M (in Ref. 2; BAC85520).
FT                                {ECO:0000305}.
FT   CONFLICT   1214   1214       S -> F (in Ref. 1; AAS79660).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1309 AA;  144282 MW;  7684E687FA8522B4 CRC64;
     MQPLTKDAGM SLSSVTLASA LQVRGEALSE EEIWSLLFLA AEQLLEDLRN DSSDYVVCPW
     SALLSAAGSL SFQGRVSHIE AAPFKAPELL QGQSEDEQPD ASQMHVYSLG MTLYWSAGFH
     VPPHQPLQLC EPLHSILLTM CEDQPHRRCT LQSVLEACRV HEKEVSVYPA PAGLHIRRLV
     GLVLGTISEV EKRVVEESSS VQQNRSYLLR KRLRGTSSES PAAQAPECLH PCRVSERSTE
     TQSSPEPHWS TLTHSHCSLL VNRALPGADP QDQQAGRRLS SGSVHSAADS SWPTTPSQRG
     FLQRRSKFSR PEFILLAGEA PMTLHLPGSV VTKKGKSYLA LRDLCVVLLN GQHLEVKCDV
     ESTVGAVFNA VTSFANLEEL TYFGLAYMKS KEFFFLDSET RLCKIAPEGW REQPQKTSMN
     TFTLFLRIKF FVSHYGLLQH SLTRHQFYLQ LRKDILEERL YCNEEILLQL GVLALQAEFG
     NYPKEQVESK PYFHVEDYIP ASLIERMTAL RVQVEVSEMH RLSSALWGED AELKFLRVTQ
     QLPEYGVLVH QVFSEKRRPE EEMALGICAK GVIVYEVKNN SRIAMLRFQW RETGKISTYQ
     KKFTITSSVT GKKHTFVTDS AKTSKYLLDL CSAQHGFNAQ MGSGQPSHVL FDHDKFVQMA
     NLSPAHQARS KPLIWIQRLS CSENELFVSR LQGAAGGLLS TSMDNFNVDG SKEAGAEGIG
     RSPCTGREQL KSACVIQKPM TWDSLSGPPV QSMHAGSKNN RRKSFIAEPG REIVRVTLKR
     DPHRGFGFVI NEGEYSGQAD PGIFISSIIP GGPAEKAKTI KPGGQILALN HISLEGFTFN
     MAVRMIQNSP DNIELIISQS KGVGGNNPDE EKNSTANSGV SSTDILSFGY QGSLLSHTQD
     QDRNTEELDM AGVQSLVPRL RHQLSFLPLK GAGSSCPPSP PEISAGEIYF VELVKEDGTL
     GFSVTGGINT SVPYGGIYVK SIVPGGPAAK EGQILQGDRL LQVDGVILCG LTHKQAVQCL
     TGPGQVARLV LERRVPRSTQ QCPSANDSMG DERTAVSLVT ALPGRPSSCV SVTDGPKFEV
     KLKKNANGLG FSFVQMEKES CSHLKSDLVR IKRLFPGQPA EENGAIAAGD IILAVNGRST
     EGLIFQEVLH LLRGAPQEVT LLLCRPPPGA LPELEQEWQT PELSADKEFT RATCTDSCTS
     PILDQEDSWR DSASPDAGEG LGLRPESSQK AIREAQWGQN RERPWASSLT HSPESHPHLC
     KLHQERDEST LATSLEKDVR QNCYSVCDIM RLGRYSFSSP LTRLSTDIF
//
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