ID   LHX9_XENLA              Reviewed;         331 AA.
AC   Q68EY3;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=LIM/homeobox protein Lhx9;
DE            Short=LIM homeobox protein 9;
GN   Name=lhx9;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in gonadal development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; BC080067; AAH80067.1; -; mRNA.
DR   RefSeq; NP_001087527.1; NM_001094058.1.
DR   AlphaFoldDB; Q68EY3; -.
DR   BMRB; Q68EY3; -.
DR   SMR; Q68EY3; -.
DR   DNASU; 447351; -.
DR   GeneID; 447351; -.
DR   KEGG; xla:447351; -.
DR   AGR; Xenbase:XB-GENE-866119; -.
DR   Xenbase; XB-GENE-866119; lhx9.S.
DR   OrthoDB; 2880952at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 447351; Expressed in brain and 4 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0097380; P:dorsal spinal cord interneuron anterior axon guidance; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   CDD; cd09469; LIM1_Lhx2; 1.
DR   CDD; cd09377; LIM2_Lhx2_Lhx9; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24208; LIM/HOMEOBOX PROTEIN LHX; 1.
DR   PANTHER; PTHR24208:SF95; LIM_HOMEOBOX PROTEIN LHX9; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Zinc.
FT   CHAIN           1..331
FT                   /note="LIM/homeobox protein Lhx9"
FT                   /id="PRO_0000364233"
FT   DOMAIN          71..132
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          133..194
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        268..327
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          253..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   331 AA;  37436 MW;  DEEE499311AD356D CRC64;
     MEIVGCRADE SAYPFRPAAA MLFHGITGGH IQGIMEEMER RSKSADSRLA KSIQVNSRET
     RMPSLNPEKP TLCAGCGGKI SDRYYLLAVD KQWHLRCLKC CECKLTLESE LTCFAKDGSI
     YCKEDYYRFS VKRCARCHLG ISASEMVMRA RESVYHLSCF TCTTCNKTLS TGDQFGMKEN
     LVYCRIHFEL LVQGDFHQQL NYTELSAKGG GIAALPYFSN GTGTVQKGRP RKRKSPALGV
     DIMNYSSGCN ENETDLDRDQ TYPPSQKTKR MRTSFKHHQL RTMKSYFAIN HNPDAKDLKQ
     LAQKTGLTKR VLQGEQCSGF NSHTTRRLKI P
//