ID Q68ST9_PLEDJ Unreviewed; 306 AA.
AC Q68ST9;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Reductase AKOR2 {ECO:0000313|EMBL:AAS46751.1};
GN Name=AKOR2 {ECO:0000313|EMBL:AAS46751.1};
OS Pleurotus djamor (Pink oyster mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=34470 {ECO:0000313|EMBL:AAS46751.1};
RN [1] {ECO:0000313|EMBL:AAS46751.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RV95/957.30 {ECO:0000313|EMBL:AAS46751.1};
RX PubMed=15219565; DOI=10.1016/j.fgb.2004.04.005;
RA James T.Y., Liou S.R., Vilgalys R.;
RT "The genetic structure and diversity of the A and B mating-type genes from
RT the tropical oyster mushroom, Pleurotus djamor.";
RL Fungal Genet. Biol. 41:813-825(2004).
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DR EMBL; AY462110; AAS46751.1; -; Genomic_DNA.
DR AlphaFoldDB; Q68ST9; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF504; GLYCEROL 2-DEHYDROGENASE (NADP(+))-RELATED; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
FT DOMAIN 18..281
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 55
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 111
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 80
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 306 AA; 33983 MW; AAFDF5E157B111DA CRC64;
MSAYPPIVLN TGARMPALAL GGWAGLTEEE RTQAKEWFLT ALKSGYRHID TAQIYYTEKS
VGNAIRESGI PREELFITTK LPWNHHSRVA ESFQKSLENL GTEYIDLYLV HFPQRVFYDE
TTDFPRNPDG SIKVVNSPTL NDVWADVETL LDTGKVKAIG VSNYSIKTLE ELLKTAKVVP
AVNQVELHPF LAQSKLLAYC KEKGIAVTAY TPTGYQTVLT DPTIVELAGK YGVSPAQIVL
AWHLSRGVAA APKSANESRQ KENLNLPFLQ PEDVAKISAL DRGQRIANKA DERGQVWGLT
LEELGW
//
