ID   Q68U48_CHEME            Unreviewed;       475 AA.
AC   Q68U48;
DT   11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2004, sequence version 1.
DT   22-FEB-2023, entry version 42.
DE   SubName: Full=Cryopyrin {ECO:0000313|EMBL:AAR03578.1};
DE   Flags: Fragment;
GN   Name=CIAS1 {ECO:0000313|EMBL:AAR03578.1};
OS   Cheirogaleus medius (Fat-tailed dwarf lemur).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Cheirogaleidae; Cheirogaleus.
OX   NCBI_TaxID=9460 {ECO:0000313|EMBL:AAR03578.1};
RN   [1] {ECO:0000313|EMBL:AAR03578.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15302403; DOI=10.1016/j.gene.2004.05.002;
RA   Anderson J.P., Mueller J.L., Rosengren S., Boyle D.L., Schaner P.,
RA   Cannon S.B., Goodyear C.S., Hoffman H.M.;
RT   "Structural, expression, and evolutionary analysis of mouse CIAS1.";
RL   Gene 338:25-34(2004).
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DR   EMBL; AY338209; AAR03578.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q68U48; -.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF19; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}.
FT   DOMAIN          6..322
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAR03578.1"
FT   NON_TER         475
FT                   /evidence="ECO:0000313|EMBL:AAR03578.1"
SQ   SEQUENCE   475 AA;  54880 MW;  3FEB4DBEB6C83847 CRC64;
     HSEPVHTVVF QGAAGIGKTI LARKIMLDWA SGKLYQDKFD YLFYIHCREV SLVTQRSLRD
     LIISCCPDPN PPVWKIVSKP SRILFLMDGF DELQGAFDEH VGALCTDWQK AERGDILLSS
     LIRKKLLPEA SLLITTRPVA LEKLQHLLDH PRHIEILGFS EAKRKEYFFK YFPDEAQARE
     AFRLIQENEV LFTMCFIPLV CWIVCTGLKQ QMESGKSLAQ TSKTTTAVYI FFLSSLLQSR
     GGSQEHPLSH HLQGLCSLAA DGIWNQKILF EESDLRNHGL QKVDVSAFLR MNLFQKEVDC
     EKFYSFVHMT FQEFFAAMYY LLEEEEEGGM RTAQGSCSKL PNRDVTVLLE NYGKFEKGYL
     IFVVRFLFGL VNRERTSYLE KKLSCKISQQ IRLELLKWME VKAKAKKLQI QPSQLELFYC
     LYEMQEEDFV QRAMNHFPKI EINLSTRMDH VVSSFCIANC RSVQSLSLGF LHNTP
//