ID Q69B60_BALBN Unreviewed; 108 AA.
AC Q69B60;
DT 13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2004, sequence version 1.
DT 22-FEB-2023, entry version 50.
DE RecName: Full=Alpha-lactalbumin {ECO:0000256|ARBA:ARBA00017299};
DE AltName: Full=Lactose synthase B protein {ECO:0000256|ARBA:ARBA00031746};
DE Flags: Fragment;
GN Name=LALBA {ECO:0000313|EMBL:AAR37338.1};
OS Balaenoptera bonaerensis (Antarctic minke whale) (Balaenoptera
OS acutorostrata subsp. bonaerensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=33556 {ECO:0000313|EMBL:AAR37338.1};
RN [1] {ECO:0000313|EMBL:AAR37338.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15288064; DOI=10.1016/j.ympev.2004.02.020;
RA Rychel A.L., Reeder T.W., Berta A.;
RT "Phylogeny of mysticete whales based on mitochondrial and nuclear data.";
RL Mol. Phylogenet. Evol. 32:892-901(2004).
CC -!- FUNCTION: Regulatory subunit of lactose synthase, changes the substrate
CC specificity of galactosyltransferase in the mammary gland making
CC glucose a good acceptor substrate for this enzyme. This enables LS to
CC synthesize lactose, the major carbohydrate component of milk. In other
CC tissues, galactosyltransferase transfers galactose onto the N-
CC acetylglucosamine of the oligosaccharide chains in glycoproteins.
CC {ECO:0000256|ARBA:ARBA00002592}.
CC -!- SUBUNIT: Lactose synthase (LS) is a heterodimer of a catalytic
CC component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory
CC component, alpha-lactalbumin (LA). {ECO:0000256|ARBA:ARBA00011582}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000256|RuleBase:RU004440}.
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DR EMBL; AY398645; AAR37338.1; -; Genomic_DNA.
DR AlphaFoldDB; Q69B60; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004461; F:lactose synthase activity; IEA:InterPro.
DR GO; GO:0005989; P:lactose biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.530.10; -; 1.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR019799; Glyco_hydro_22_CS.
DR InterPro; IPR000545; Lactalbumin.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR PANTHER; PTHR11407:SF32; ALPHA-LACTALBUMIN; 1.
DR PANTHER; PTHR11407; LYSOZYME C; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00136; LACTALBUMIN.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lactose biosynthesis {ECO:0000256|ARBA:ARBA00023091};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Milk protein {ECO:0000256|ARBA:ARBA00022743}.
FT DOMAIN 87..105
FT /note="Glycosyl hydrolases family 22 (GH22)"
FT /evidence="ECO:0000259|PROSITE:PS00128"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAR37338.1"
FT NON_TER 108
FT /evidence="ECO:0000313|EMBL:AAR37338.1"
SQ SEQUENCE 108 AA; 12195 MW; 81CD85CCD18172DC CRC64;
SLLLVGNLFH AIQAEQLTKC EVFQRLKDLD GYGGITLPEW VCTVFHTSGC DTQTVVNNNG
STEYGLFQIN NKIWCRDNHI PHSRDICGIS CDKFLDDDLT DDIMCVKK
//
