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Database: UniProt
Entry: Q69MX6_ORYSJ
LinkDB: Q69MX6_ORYSJ
Original site: Q69MX6_ORYSJ 
ID   Q69MX6_ORYSJ            Unreviewed;      1253 AA.
AC   Q69MX6;
DT   13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2004, sequence version 1.
DT   24-JAN-2024, entry version 108.
DE   RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN   ORFNames=OJ1261_A08.53 {ECO:0000313|EMBL:BAD36299.1}, P0465E03.5
GN   {ECO:0000313|EMBL:BAD36244.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947 {ECO:0000313|EMBL:BAD36299.1, ECO:0000313|Proteomes:UP000000763};
RN   [1] {ECO:0000313|EMBL:BAD36299.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sasaki T., Matsumoto T., Hattori M., Sakaki Y., Katayose Y.;
RT   "Oryza sativa nipponbare(GA3) genomic DNA, chromosome 9, BAC
RT   clone:OJ1261_A08.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAD36244.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sasaki T., Matsumoto T., Katayose Y.;
RT   "Oryza sativa nipponbare(GA3) genomic DNA, chromosome 9, PAC
RT   clone:P0465E03.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000000763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare {ECO:0000313|Proteomes:UP000000763};
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RA   Matsumoto T., Wu J., Kanamori H., Katayose Y., Fujisawa M., Namiki N.,
RA   Mizuno H., Yamamoto K., Antonio B.A., Baba T., Sakata K., Nagamura Y.,
RA   Aoki H., Arikawa K., Arita K., Bito T., Chiden Y., Fujitsuka N.,
RA   Fukunaka R., Hamada M., Harada C., Hayashi A., Hijishita S., Honda M.,
RA   Hosokawa S., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M.,
RA   Ito K., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K.,
RA   Karasawa W., Kurita K., Katagiri S., Kikuta A., Kobayashi H., Kobayashi N.,
RA   Machita K., Maehara T., Masukawa M., Mizubayashi T., Mukai Y., Nagasaki H.,
RA   Nagata Y., Naito S., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M.,
RA   Meguro A., Negishi M., Ohta I., Ohta T., Okamoto M., Ono N., Saji S.,
RA   Sakaguchi M., Sakai K., Shibata M., Shimokawa T., Song J., Takazaki Y.,
RA   Terasawa K., Tsugane M., Tsuji K., Ueda S., Waki K., Yamagata H.,
RA   Yamamoto M., Yamamoto S., Yamane H., Yoshiki S., Yoshihara R., Yukawa K.,
RA   Zhong H., Yano M., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA   Moffat K., Hill J., Bera J., Fadrosh D., Jin S., Johri S., Kim M.,
RA   Overton L., Reardon M., Tsitrin T., Vuong H., Weaver B., Ciecko A.,
RA   Tallon L., Jackson J., Pai G., Aken S.V., Utterback T., Reidmuller S.,
RA   Feldblyum T., Hsiao J., Zismann V., Iobst S., de Vazeille A.R., Buell C.R.,
RA   Ying K., Li Y., Lu T., Huang Y., Zhao Q., Feng Q., Zhang L., Zhu J.,
RA   Weng Q., Mu J., Lu Y., Fan D., Liu Y., Guan J., Zhang Y., Yu S., Liu X.,
RA   Zhang Y., Hong G., Han B., Choisne N., Demange N., Orjeda G., Samain S.,
RA   Cattolico L., Pelletier E., Couloux A., Segurens B., Wincker P., D'Hont A.,
RA   Scarpelli C., Weissenbach J., Salanoubat M., Quetier F., Yu Y., Kim H.R.,
RA   Rambo T., Currie J., Collura K., Luo M., Yang T., Ammiraju J.S.S.,
RA   Engler F., Soderlund C., Wing R.A., Palmer L.E., de la Bastide M.,
RA   Spiegel L., Nascimento L., Zutavern T., O'Shaughnessy A., Dike S.,
RA   Dedhia N., Preston R., Balija V., McCombie W.R., Chow T., Chen H.,
RA   Chung M., Chen C., Shaw J., Wu H., Hsiao K., Chao Y., Chu M., Cheng C.,
RA   Hour A., Lee P., Lin S., Lin Y., Liou J., Liu S., Hsing Y., Raghuvanshi S.,
RA   Mohanty A., Bharti A.K., Gaur A., Gupta V., Kumar D., Ravi V., Vij S.,
RA   Kapur A., Khurana P., Khurana P., Khurana J.P., Tyagi A.K., Gaikwad K.,
RA   Singh A., Dalal V., Srivastava S., Dixit A., Pal A.K., Ghazi I.A.,
RA   Yadav M., Pandit A., Bhargava A., Sureshbabu K., Batra K., Sharma T.R.,
RA   Mohapatra T., Singh N.K., Messing J., Nelson A.B., Fuks G., Kavchok S.,
RA   Keizer G., Linton E., Llaca V., Song R., Tanyolac B., Young S., Ho-Il K.,
RA   Hahn J.H., Sangsakoo G., Vanavichit A., de Mattos Luiz.A.T., Zimmer P.D.,
RA   Malone G., Dellagostin O., de Oliveira A.C., Bevan M., Bancroft I.,
RA   Minx P., Cordum H., Wilson R., Cheng Z., Jin W., Jiang J., Leong S.A.,
RA   Iwama H., Gojobori T., Itoh T., Niimura Y., Fujii Y., Habara T., Sakai H.,
RA   Sato Y., Wilson G., Kumar K., McCouch S., Juretic N., Hoen D., Wright S.,
RA   Bruskiewich R., Bureau T., Miyao A., Hirochika H., Nishikawa T.,
RA   Kadowaki K., Sugiura M., Burr B., Sasaki T.;
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4] {ECO:0000313|Proteomes:UP000000763}
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare {ECO:0000313|Proteomes:UP000000763};
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
CC   -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC       (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR   EMBL; AP005707; BAD36244.1; -; Genomic_DNA.
DR   EMBL; AP005722; BAD36299.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q69MX6; -.
DR   Proteomes; UP000000763; Chromosome 9.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd20404; Tudor_Agenet_AtEML-like; 1.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002999; Tudor.
DR   PANTHER; PTHR11361:SF150; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00333; TUDOR; 1.
DR   SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR   SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW   DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR037677}.
FT   DOMAIN          65..123
FT                   /note="Tudor"
FT                   /evidence="ECO:0000259|SMART:SM00333"
FT   DOMAIN          636..977
FT                   /note="DNA mismatch repair protein MutS core"
FT                   /evidence="ECO:0000259|SMART:SM00533"
FT   DOMAIN          997..1188
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|SMART:SM00534"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..63
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..198
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1253 AA;  138526 MW;  6CE7D78D4ADF7248 CRC64;
     MASPSSRRLS NGRSPLLRKQ SQITAFFSSP TAKPSPSPLN PRATKPPLAV PSPPPPNPPS
     PPQEEETAVG RRLRVYWPLD DAWYEGRVEG YDVGSRRHRV RYDDGEEEVV DLASERYEWA
     AAADEEEVTP QPSRKLRRLR RMSDAATAKS PGAVDGGGGG DETADSAEEE DEDWKNDAAA
     ENDSEEVELD DEEDDEEEVV AVKTRKGKKN NPLSTSASTP KLASGLGSAS ISGSTLSKKR
     RKVDAGEQPL ENALTALTGE VAERFAQRQA EKFKFLGEGR KDAKGRRPGN PNYDPRTLSL
     PSQFLNSLTG GQRQWWEFKS QHMDKVLFFK MGKFYELFEM DAHVGAKELD LQYMKGDKPH
     CGFPEKNFEL NLEKLAKKGY RVLVIEQTET PEQLDLRRKE TGVKDKVVRR EICAMVTKGT
     LTEGESLLAN PDPSYLFSVA ESYQCGSEKD QDGHTIGVCI VDVSTSKFIV GQFQDDAERH
     GLCSILSEIR PAEIIKPAKM LSPETEKALK SNTRDPLINN LLPSMEFWDA EKTIHEIKQY
     YCSLDTPGAG AQISSAYLPE LLSELIEAGD KTYALSALGG SLFYLRQSLL DEKLLPCAEF
     ERLTCSGLTN PIRKHMILDA AALENLEILE NARNGGLSGT LYAQLNHCVT GFGKRLLKRW
     IARPLYERQA ILQRQSAIAT FKGSGHECAI QFRKDLSRLP DMERLLARLF SSCDKNGRSS
     KSVVLYEDAS KRLLHQFTAA LRGCQQMFQA CSSISMLTST DGSSLLNDLL SLGKGLPHVS
     SILDHFRDAF DWSEADRNGR IIPHEGCDPQ YDAACIAIEE IESSLQKYLK EQRKLLSDSS
     VKYVDVGKDT YLLEVSENLR GSVPHNYELQ STKKGFYRYW TPEVKELISE LSKAEAEKEA
     KLKCILQNLI QLFVEHHSKW RQLVSVVAEL DVLISLAIAS DFFEGPTCCP IIKESYGPDD
     TPTLHARNLG HPTLRSDSLG SGSFVPNDIK MGGPGNASFI VLTGPNMGGK STLLRQVCLT
     IILAQIGANV PAESFELSLV DRMFVRMGAR DHIMAGQSTF LVELMETASV LSSATKNSLV
     ALDELGRGTS TSDGQAIAAS VLEYLVHHVQ CLGLFSTHYH RLAAENKDSK VSLCHMACEI
     SKGEGGLEEV TFLYKLTPGS CPKSYGVNVA RLAGIPASVL QRANEKSSDF EASYGKRPGI
     TKNKPSCAQE DKFAAIKDLF RVVKAMHHRE DHASSLGMLH EVQKRAKVQV IGE
//
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