ID Q6BC47_9HIV1 Unreviewed; 853 AA.
AC Q6BC47;
DT 13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2004, sequence version 1.
DT 24-JAN-2024, entry version 107.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAT67484.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAT67484.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAT67484.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VLGC-B1 {ECO:0000313|EMBL:AAT67484.1};
RX PubMed=15542675; DOI=10.1128/JVI.78.23.13232-13252.2004;
RA Binley J.M., Wrin T., Korber B., Zwick M.B., Wang M., Chappey C.,
RA Stiegler G., Kunert R., Zolla-Pazner S., Katinger H., Petropoulos C.J.,
RA Burton D.R.;
RT "Comprehensive cross-clade neutralization analysis of a panel of anti-human
RT immunodeficiency virus type 1 monoclonal antibodies.";
RL J. Virol. 78:13232-13252(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AY669712; AAT67484.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:UniProtKB-KW.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR HAMAP; MF_04083; HIV_ENV; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR037527; Gp160.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Clathrin-mediated endocytosis of virus by host
KW {ECO:0000256|ARBA:ARBA00022570};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Viral envelope protein {ECO:0000313|EMBL:AAT67484.1};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022570};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022570}.
FT DOMAIN 33..507
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 527..716
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 717..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 853
FT /evidence="ECO:0000313|EMBL:AAT67484.1"
SQ SEQUENCE 853 AA; 96250 MW; 407F9EA1B9DE6864 CRC64;
MRAKETXXNY HYLWKWGLMI IGMLMICSAT EQLWVTVYYG VPVWKEATTT LFCASDAKAV
NTEVHNVWAT HACVPTDPNP QEXXLXNVTE NFXMWKNNMV EQMHEDIISL WDQSLKPCVK
LTPLCVTLNC TBWKLXNTIB NXTTLNNNNS TDMKNCXXNV TTXIRNXIQX EXALFYNLDV
APIDBXTSYT LINCNTTVIT QACPKVSFEP IPIHYCAPAG FVILKCNDKN FNGTGPCNNV
STVQCTHGIR PVVSTQLLLN GSLAEDEIVX RSENFTDNAK TIIVHLNXTX XINCTRPGNN
TRKSIHIGPG KAMYATGSII GBXRQAHCTI NGTXWXDXLE QIAIKLGKQF NSTIXFBQSS
GGDPEITMHS FNCGGEFFYC BTTQLFNSTW XXXSTLNTAX STWNITQNVT LPCRIKQIIN
RWQEVGKAMY APPISGYINC SSNITGLLLT RDGGNXNXSX NETFRPGGGD MXDNWRSELY
KYKVVXIEPL GVAPTKAXRR VVQREKRAXG XIGAMFLGFL GAAGSTMGAA SXTLTVQARQ
LLSGIVQQQN NLLRAIEAQQ HLLQLTVWGI KQLQARVLAV ERYLXDQQLL GIWGCSGKLI
CTTAVPWNAS WSNKXLXQIW XNMTWMQWEX EIDNYTEVIY TLIXESQNQQ EXNEKELLEL
DKWASLWXWF DISNWLWYIK IFIXIVGGLI GLRXVFXVLS IVNRVRQGYS PLSFQTRLPT
QRGPDRPEGI DAEGGDRGRD GSIRLVDGFL AIIWDDLRSL CLFLYQRLSD LLLIVTRIVE
LLGRRXWEAL KYWWNLLQYW SQELKNSAVS LLNATAIAVA EGTDRVIEXV QRIGRAILHV
PTRIRQGLER ALL
//