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Database: UniProt
Entry: Q6BC47_9HIV1
LinkDB: Q6BC47_9HIV1
Original site: Q6BC47_9HIV1 
ID   Q6BC47_9HIV1            Unreviewed;       853 AA.
AC   Q6BC47;
DT   13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2004, sequence version 1.
DT   24-JAN-2024, entry version 107.
DE   RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE   AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:AAT67484.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAT67484.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAT67484.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=VLGC-B1 {ECO:0000313|EMBL:AAT67484.1};
RX   PubMed=15542675; DOI=10.1128/JVI.78.23.13232-13252.2004;
RA   Binley J.M., Wrin T., Korber B., Zwick M.B., Wang M., Chappey C.,
RA   Stiegler G., Kunert R., Zolla-Pazner S., Katinger H., Petropoulos C.J.,
RA   Burton D.R.;
RT   "Comprehensive cross-clade neutralization analysis of a panel of anti-human
RT   immunodeficiency virus type 1 monoclonal antibodies.";
RL   J. Virol. 78:13232-13252(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC       membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004563}.
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DR   EMBL; AY669712; AAT67484.1; -; Genomic_DNA.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:UniProtKB-KW.
DR   CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR   Gene3D; 1.10.287.210; -; 1.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR   Gene3D; 1.20.5.490; Single helix bin; 1.
DR   HAMAP; MF_04083; HIV_ENV; 1.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR037527; Gp160.
DR   InterPro; IPR000328; GP41-like.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 1.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF56502; gp120 core; 1.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Clathrin-mediated endocytosis of virus by host
KW   {ECO:0000256|ARBA:ARBA00022570};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Fusion of virus membrane with host endosomal membrane
KW   {ECO:0000256|ARBA:ARBA00022510};
KW   Fusion of virus membrane with host membrane
KW   {ECO:0000256|ARBA:ARBA00022510};
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Viral envelope protein {ECO:0000313|EMBL:AAT67484.1};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW   Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022570};
KW   Virion {ECO:0000256|ARBA:ARBA00022844};
KW   Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00022570}.
FT   DOMAIN          33..507
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   DOMAIN          527..716
FT                   /note="Retroviral envelope protein GP41-like"
FT                   /evidence="ECO:0000259|Pfam:PF00517"
FT   REGION          717..736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         853
FT                   /evidence="ECO:0000313|EMBL:AAT67484.1"
SQ   SEQUENCE   853 AA;  96250 MW;  407F9EA1B9DE6864 CRC64;
     MRAKETXXNY HYLWKWGLMI IGMLMICSAT EQLWVTVYYG VPVWKEATTT LFCASDAKAV
     NTEVHNVWAT HACVPTDPNP QEXXLXNVTE NFXMWKNNMV EQMHEDIISL WDQSLKPCVK
     LTPLCVTLNC TBWKLXNTIB NXTTLNNNNS TDMKNCXXNV TTXIRNXIQX EXALFYNLDV
     APIDBXTSYT LINCNTTVIT QACPKVSFEP IPIHYCAPAG FVILKCNDKN FNGTGPCNNV
     STVQCTHGIR PVVSTQLLLN GSLAEDEIVX RSENFTDNAK TIIVHLNXTX XINCTRPGNN
     TRKSIHIGPG KAMYATGSII GBXRQAHCTI NGTXWXDXLE QIAIKLGKQF NSTIXFBQSS
     GGDPEITMHS FNCGGEFFYC BTTQLFNSTW XXXSTLNTAX STWNITQNVT LPCRIKQIIN
     RWQEVGKAMY APPISGYINC SSNITGLLLT RDGGNXNXSX NETFRPGGGD MXDNWRSELY
     KYKVVXIEPL GVAPTKAXRR VVQREKRAXG XIGAMFLGFL GAAGSTMGAA SXTLTVQARQ
     LLSGIVQQQN NLLRAIEAQQ HLLQLTVWGI KQLQARVLAV ERYLXDQQLL GIWGCSGKLI
     CTTAVPWNAS WSNKXLXQIW XNMTWMQWEX EIDNYTEVIY TLIXESQNQQ EXNEKELLEL
     DKWASLWXWF DISNWLWYIK IFIXIVGGLI GLRXVFXVLS IVNRVRQGYS PLSFQTRLPT
     QRGPDRPEGI DAEGGDRGRD GSIRLVDGFL AIIWDDLRSL CLFLYQRLSD LLLIVTRIVE
     LLGRRXWEAL KYWWNLLQYW SQELKNSAVS LLNATAIAVA EGTDRVIEXV QRIGRAILHV
     PTRIRQGLER ALL
//
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