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Database: UniProt
Entry: Q6BIX9_DEBHA
LinkDB: Q6BIX9_DEBHA
Original site: Q6BIX9_DEBHA 
ID   Q6BIX9_DEBHA            Unreviewed;       943 AA.
AC   Q6BIX9;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   04-NOV-2008, sequence version 2.
DT   07-JUN-2017, entry version 73.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=DEHA2G06776g {ECO:0000313|EMBL:CAG90303.2};
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592 {ECO:0000313|EMBL:CAG90303.2, ECO:0000313|Proteomes:UP000000599};
RN   [1] {ECO:0000313|EMBL:CAG90303.2, ECO:0000313|Proteomes:UP000000599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968
RC   {ECO:0000313|Proteomes:UP000000599};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CR382139; CAG90303.2; -; Genomic_DNA.
DR   RefSeq; XP_461842.2; XM_461842.1.
DR   EnsemblFungi; CAG90303; CAG90303; DEHA2G06776g.
DR   GeneID; 2904721; -.
DR   KEGG; dha:DEHA2G06776g; -.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; Q6BIX9; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000599};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000599};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    499    522       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    543    562       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    630    650       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    662    683       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    723    742       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    850    869       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    881    904       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   943 AA;  108161 MW;  DF5A51E53CFC9D53 CRC64;
     MLPISSQQGQ DNGQEEAIFR SAPMTLVQFY VTIELARDVV YALGKLGDVH FRDLNSKLTP
     FQRTFVNELR GIDKIESHLE YLRSTMTKYD TIGATPYSSL QADQRPLPSA SEMDNIRAEV
     TTFYERIKHL DSSYNSLDQQ KLKYVENRYV VTAVNRFHSS SLTREDDIDQ RFAIHGDTDD
     EDNIALLNNR NNSLENPVID AAILEDSGFN SISGSIAREK VPLLRNILWR TLRGNLFFHD
     IPIEDEKMSN FSSKNTEFID KNVFIVYIHG EFLKQRVRRI IQSLDGIIYD NVNGGSSARA
     ETLSDLNHKI EDLNNVVQST REHLIADLLI FQEGYLDRCY SVQREKLIYQ TLNKFDMDGT
     RRCLVGEGWI PKSEFSTCQQ TFRNLIHQKS RHVIPENNSQ ESISLSADNT GARSTPEPQN
     TDESFAIGNA NVDETMDIEN EDYNSLVAVV NELSTNRTPP TYHKTNKFTS AFQSIIDAYG
     IATYQEVNPG LATVITFPFM FAIMFGDLGH GFIVFLISLY LIKNESHFGP MKNKDEIFEM
     AFNGRYIVLL MGFFSMYTGF IYNDIFSKSM SFFKSGWEWN FPKDYDFGKD GPITLIAKKI
     PGHTYIFGLD WAWHGADNNL LFTNSYKMKL SILMGFIHMN YSLFFSLVNY RYFKSKVDII
     GNFIPGFLFM QSIFGYLSLT IIYKWSVDWL GKEKQPPGLL NMLINMFLAP GSIDEQLYPG
     QKFVQIVLVL IAAVCVPWLL LYKPMTLKRQ NNKALELGYS DLHSQMNHSL QMHEEEEAIM
     LENQLNSDPP DEVDMLDDNF RFPNDVEPLF HNSAHSDDHD SFNFGDIVIH QVIHTIEFCL
     NCVSHTASYL RLWALSLAHA QLSTVLWSMT IQNAFGTYGG WGVFMTVVLF GMWFILTVCI
     LVLMEGTSAM LHSLRLHWVE AMSKFFEGEG YAYEPFTFES IDI
//
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