ID Q6BZT1_YARLI Unreviewed; 804 AA.
AC Q6BZT1;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=YALI0_F31119g {ECO:0000313|EMBL:CAG78894.1};
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591 {ECO:0000313|EMBL:CAG78894.1, ECO:0000313|Proteomes:UP000001300};
RN [1] {ECO:0000313|EMBL:CAG78894.1, ECO:0000313|Proteomes:UP000001300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150 {ECO:0000313|Proteomes:UP000001300};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382132; CAG78894.1; -; Genomic_DNA.
DR RefSeq; XP_506081.1; XM_506081.1.
DR AlphaFoldDB; Q6BZT1; -.
DR STRING; 284591.Q6BZT1; -.
DR EnsemblFungi; CAG78894; CAG78894; YALI0_F31119g.
DR GeneID; 2907662; -.
DR KEGG; yli:YALI0F31119g; -.
DR VEuPathDB; FungiDB:YALI0_F31119g; -.
DR HOGENOM; CLU_005230_0_2_1; -.
DR InParanoid; Q6BZT1; -.
DR OMA; FYLWFFL; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000001300; Chromosome F.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:EnsemblFungi.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR GO; GO:0071474; P:cellular hyperosmotic response; IEA:EnsemblFungi.
DR GO; GO:0071469; P:cellular response to alkaline pH; IEA:EnsemblFungi.
DR GO; GO:0006797; P:polyphosphate metabolic process; IEA:EnsemblFungi.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:EnsemblFungi.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000001300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 389..414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 435..452
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 511..533
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 540..560
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 603..623
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 709..726
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 732..762
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 658..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 110..137
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 804 AA; 91132 MW; BC4EBFFBDBEAED57 CRC64;
MPESNQSGEA IFRSAEMSLV QLYIASEIGR ETVMSLGELG LVQFRDLNKK VNVFQRNFIQ
EVRRLDNVDR QLRLFERECE KEGLTLEDGD PHSAASASDI DALVALGDTL EKRITELRDA
EERVTESQTE SQELRAVLTE TAKFFDQRAG GGSRDIESQS LRNVQFVAGV IPRDRVEVLE
RILWRVLRGN LFLETAEFGG DDGDKSVFIV FSHGAEIISK VERIAKTLDA HLYWIADDVR
ERENQLQEVN QKLSDIDIVS QRTRHTLNTE LRLIAQKLPN WRVIVIKEKS VYSTLNLFQY
DTNRKVLIGE GWVPKDDISK VKTTLKSITD EADVEIPSVL NVLETSRTPP TYHRTNKFTS
AFQLIVDAYG ISSYREVNPG LPTIVTFPFM FAIMFGDIGH GFILFLAAFA LVYYEAKIGK
MKRDEIFDMA YQGRYILLLM GAFSMYTGFM YNDIFSKSMT LFKPGWAWPE SWKEGQTIQA
HQTGVYAFGL DPTWHGTDNN LLFTNSYKMK LSVLMGHVHM TYSFFLSLVN YIFFGSVVDF
WGNFVPGLLF MQGIFGYLAL TIVYKWTVDW VAIGQQPPSL LDTLINMFLA PGKVPVPLYP
GQAYVQVILV VIALICVPWL LLVKPLWLRR DMQKHEYERV SGNGGPLDLL DAPDQLEETV
GDTPGDATGG DDFDDEEEEE HGFGDIVIHQ VIHTIEFCLN CVSHTASYLR LWALSLAHAQ
LSTVLWDMTL QAAFGFSGVV GVIMTVILFG MWFVLTVVIL VCMEGTSAML HSLRLHWVES
MSKFFEGEGT PYEPFSFKDE LATN
//
