ID Q6C3F6_YARLI Unreviewed; 887 AA.
AC Q6C3F6;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 114.
DE SubName: Full=YALI0F00154p {ECO:0000313|EMBL:CAG77608.1};
GN ORFNames=YALI0_F00154g {ECO:0000313|EMBL:CAG77608.1};
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591 {ECO:0000313|EMBL:CAG77608.1, ECO:0000313|Proteomes:UP000001300};
RN [1] {ECO:0000313|EMBL:CAG77608.1, ECO:0000313|Proteomes:UP000001300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150 {ECO:0000313|Proteomes:UP000001300};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382132; CAG77608.1; -; Genomic_DNA.
DR RefSeq; XP_504806.1; XM_504806.1.
DR AlphaFoldDB; Q6C3F6; -.
DR STRING; 284591.Q6C3F6; -.
DR EnsemblFungi; CAG77608; CAG77608; YALI0_F00154g.
DR GeneID; 2908552; -.
DR KEGG; yli:YALI0F00154g; -.
DR VEuPathDB; FungiDB:YALI0_F00154g; -.
DR HOGENOM; CLU_002472_10_0_1; -.
DR InParanoid; Q6C3F6; -.
DR OMA; LVRFPQK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000001300; Chromosome F.
DR GO; GO:0032301; C:MutSalpha complex; IBA:GO_Central.
DR GO; GO:0032302; C:MutSbeta complex; IEA:EnsemblFungi.
DR GO; GO:0000228; C:nuclear chromosome; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:EnsemblFungi.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0000406; F:double-strand/single-strand DNA junction binding; IEA:EnsemblFungi.
DR GO; GO:0000400; F:four-way junction DNA binding; IEA:EnsemblFungi.
DR GO; GO:0032137; F:guanine/thymine mispair binding; IEA:EnsemblFungi.
DR GO; GO:0000404; F:heteroduplex DNA loop binding; IEA:EnsemblFungi.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0032138; F:single base insertion or deletion binding; IEA:EnsemblFungi.
DR GO; GO:0000403; F:Y-form DNA binding; IEA:EnsemblFungi.
DR GO; GO:0007534; P:gene conversion at mating-type locus; IEA:EnsemblFungi.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:EnsemblFungi.
DR GO; GO:0043570; P:maintenance of DNA repeat elements; IEA:EnsemblFungi.
DR GO; GO:0006311; P:meiotic gene conversion; IEA:EnsemblFungi.
DR GO; GO:0000710; P:meiotic mismatch repair; IEA:EnsemblFungi.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR GO; GO:0000735; P:removal of nonhomologous ends; IEA:EnsemblFungi.
DR GO; GO:0043111; P:replication fork arrest; IEA:EnsemblFungi.
DR GO; GO:0030466; P:silent mating-type cassette heterochromatin formation; IEA:EnsemblFungi.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001300}.
FT DOMAIN 706..722
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 887 AA; 98687 MW; 557FD4A201F3F2EF CRC64;
MSRPEFNIDK TEERSLTAFY KGLEEREEPC DNGGTIRVFE RPDGYVLFGV DARYVAERVY
RTLTALKTTD LKQEYVTIAT SGFQNFLRDA LLNYGLKVEI YGKVDGKWRM TSWGSPGNLS
QVEDLMSGQL NTNPVAIAVK TQGDTVGLAF VDLNNHVLGV SEFEDNECMS NLESLLIQLD
VKECITSDDK VKAVIERAGV SRTDAKSSWF NANEVESNLD NLLAEKLQPT SPELSLKNAL
GSLACLIKYL SLTSDASNHG AFTIKTHTLS QYMKLDASAL KALHLMPSVK DSTKSSSLYG
LLNVCKTATG SRTLAQWVKQ PLMDKQEIEK RHEIVEIFTS SDLLESIRQN LSTIPDLNRL
TRKFMRQAAS LEDVVRVYQM VATLPHIASG LRAAQSELLE ETFLTQLDSI ITGLQKFEEL
VESTIDLNSI DSHEFMINPD MEEGLNDTKA RLEACQDRMK DIFASVSDEL GMEMDKKLKF
ENHHVHGWSF RLTRTDASCL RGLSKFKELA TLKAGIIFTT NELRSLSNEF TDLSQEYKKI
QARLAKEIIE IACSYCPLLE RCSAVLGQLD VLTSFASVAI ERNYIRPTVV DSDDRKCILT
ASRHPCLEAQ DTFIPNDVHL GQDSKKFLVI TGPNMGGKST FIRQVGVIVL MNQIGCFVPC
DRAEISIFDC ILARVGAGDS QLKGLSTFMS EMLETSAILK SATDKSLIII DELGRGTSTY
DGFGLAWAIS EHIVKMNCFS MFATHFHELT ELAKEHPDRV DNLHVAAHVG ESSDDITLLY
KVVPGVSSKS YGTHVAEVVK FPTKVVNMAK RKAQELDDVN SGTQGKKYAS EDLVAGNKLL
KEILTEWKSQ IKGDEVDGAS QLLKTVVDKY KTQMEQNVFI NDALASL
//
