ID PPID_YARLI Reviewed; 367 AA.
AC Q6CBP4;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 01-MAY-2013, entry version 64.
DE RecName: Full=Peptidyl-prolyl cis-trans isomerase D;
DE Short=PPIase D;
DE EC=5.2.1.8;
DE AltName: Full=Rotamase D;
GN Name=CPR6; OrderedLocusNames=YALI0C16775g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida
OS lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes
CC the cis-trans isomerization of proline imidic peptide bonds in
CC oligopeptides (By similarity).
CC -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC (omega=0).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase
CC D subfamily.
CC -!- SIMILARITY: Contains 1 PPIase cyclophilin-type domain.
CC -!- SIMILARITY: Contains 3 TPR repeats.
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DR EMBL; CR382129; CAG82238.1; -; Genomic_DNA.
DR RefSeq; XP_501918.1; XM_501918.1.
DR ProteinModelPortal; Q6CBP4; -.
DR SMR; Q6CBP4; 3-170.
DR STRING; 4952.Q6CBP4; -.
DR PRIDE; Q6CBP4; -.
DR GeneID; 2909297; -.
DR KEGG; yli:YALI0C16775g; -.
DR eggNOG; COG0457; -.
DR HOGENOM; HOG000065980; -.
DR KO; K05864; -.
DR OMA; CKLKLSD; -.
DR OrthoDB; EOG4J9R7J; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-KW.
DR GO; GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR002130; Cyclophilin-like_PPIase_dom.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR013026; TPR-contain_dom.
DR InterPro; IPR011990; TPR-like_helical.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF00160; Pro_isomerase; 1.
DR Pfam; PF07719; TPR_2; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SUPFAM; SSF50891; CSA_PPIase; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Isomerase; Reference proteome; Repeat;
KW Rotamase; TPR repeat.
FT CHAIN 1 367 Peptidyl-prolyl cis-trans isomerase D.
FT /FTId=PRO_0000232952.
FT DOMAIN 7 171 PPIase cyclophilin-type.
FT REPEAT 213 246 TPR 1.
FT REPEAT 264 297 TPR 2.
FT REPEAT 302 335 TPR 3.
SQ SEQUENCE 367 AA; 40061 MW; 34FBD2C5DC9F24F7 CRC64;
MTNPRVFFEV AIGGKTIGKI YFELFADKVP KTAENFRALC TGEKGNTQAG IPLHFKGSSF
HRVIKDFMVQ GGDFTAGNGT GGESIYGEKF PDEAFPYPHD QPFLLSMANA GPNTNGSQFF
ITTTETPHLD NKHVVFGKLL SGKGIVRQIE RTETGEQDRP KQPVTIVDCG ELPADFQVPV
GNVDDGTGDD YEDFLKDNDN VDVNDPASVL GAIEKLKSIG TKLFKEGNAE GALKKYLKAT
TYLEDYLPDD LSEENIAKVH ALRISCYLNV ALMALKVNQP KVAIKAATSA LDDETVANKE
KAKALFRRGS GYAALKNETD ALKDLNAALE LEPADGAIKN KIEEVKQAAQ RRREAEKKKY
AGFFGGK
//
