ID VTS1_YARLI Reviewed; 437 AA.
AC Q6CHK0;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE RecName: Full=RNA-binding protein VTS1;
GN Name=VTS1; OrderedLocusNames=YALI0A08063g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: RNA-binding protein involved in post-transcriptional
CC regulation through transcript degradation.
CC {ECO:0000250|UniProtKB:Q08831}.
CC -!- SUBUNIT: Monomer. Binds to RNA. {ECO:0000250|UniProtKB:Q08831}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body
CC {ECO:0000250|UniProtKB:J9VVN9}.
CC -!- SIMILARITY: Belongs to the VTS1 family. {ECO:0000305}.
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DR EMBL; CR382127; CAG83787.1; -; Genomic_DNA.
DR RefSeq; XP_499861.1; XM_499861.1.
DR AlphaFoldDB; Q6CHK0; -.
DR SMR; Q6CHK0; -.
DR STRING; 284591.Q6CHK0; -.
DR EnsemblFungi; CAG83787; CAG83787; YALI0_A08063g.
DR GeneID; 2906106; -.
DR KEGG; yli:YALI0A08063g; -.
DR VEuPathDB; FungiDB:YALI0_A08063g; -.
DR HOGENOM; CLU_627317_0_0_1; -.
DR InParanoid; Q6CHK0; -.
DR OMA; KREQATH; -.
DR OrthoDB; 1351201at2759; -.
DR Proteomes; UP000001300; Chromosome A.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd09556; SAM_VTS1_fungal; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037635; VTS1_SAM.
DR PANTHER; PTHR12515:SF5; PROTEIN SMAUG; 1.
DR PANTHER; PTHR12515; STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleotide-binding; Protein transport; Reference proteome;
KW RNA-binding; Transport.
FT CHAIN 1..437
FT /note="RNA-binding protein VTS1"
FT /id="PRO_0000081457"
FT DOMAIN 367..428
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 46606 MW; 500CC4F1157696A7 CRC64;
MNIPRFMPGH VLHTSEDIPQ SESPLAGRRT RPVSEAFSSS YRHSDLGGYP PYGLGGSATA
GLGSLSAGMG NLNLGGTTPG LQHLGGGLAN TATMDSEKWL QDLELYNAIL EEMATVSLDK
DFKDELSSIE QWFGVLSDGE RTAALYALLQ QTNPVQIRFF ITVLQKFGNM DFDGSPIGNS
FENGAPQQQQ QTSAQPSPMG QGAMGQAMTG GLGGLGGLHP HQTTHSNLNP NAHNPIYAPV
GTFPSTPSHK HTSSLSTEPI GSRRSMIATP EHDLNAQIAN TTAMKLAALS TVSNRASLDD
RSKRSSFHQH TNSQESTPTK PGTPGGSPAP GAHSLATPMK GHHQTSSSSS ITQLSGASSA
SPATDIKLLR DVSAWLRALR LHKYTECFKD MEWQDIVQLD DAQLEEKGVN ALGARRKMLK
VFEQVRDAQK DGTLGGV
//
