ID Q6CJ23_KLULA Unreviewed; 558 AA.
AC Q6CJ23;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 105.
DE SubName: Full=KLLA0F22088p {ECO:0000313|EMBL:CAG98774.1};
GN ORFNames=KLLA0_F22088g {ECO:0000313|EMBL:CAG98774.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAG98774.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAG98774.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; CR382126; CAG98774.1; -; Genomic_DNA.
DR RefSeq; XP_456066.1; XM_456066.1.
DR AlphaFoldDB; Q6CJ23; -.
DR PaxDb; 284590-Q6CJ23; -.
DR GeneID; 2895399; -.
DR KEGG; kla:KLLA0_F22088g; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_023427_0_0_1; -.
DR InParanoid; Q6CJ23; -.
DR OMA; GYPIVPL; -.
DR Proteomes; UP000000598; Chromosome F.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47965:SF105; ASPARTIC PROTEINASE YAPSIN-7; 1.
DR PANTHER; PTHR47965; ASPARTYL PROTEASE-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..558
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004271555"
FT TRANSMEM 539..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..418
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 491..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 334..381
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 558 AA; 60599 MW; E8D558CE0A0D9FAD CRC64;
MENYLVSLAL VFLVHFALAA DADTPSVVVG SDYSGLYYVN STFGTPGQEQ RLRIDLSQPY
IWLVSGEIYP QCNKLGSGCL NGSLYYPLQS TTSNLVDDDY IRLQFLDLIS INGTKYRDNM
NFTQLSTLKN GTSLNDSNVL WNETQGWLTI NSTSFILANE TGSLVHGALG LSGPISVPAS
DSVSSLNFDD SYYFLTHLKN AGVIETSSYS LWVNNASNHS VDGQINRANA GTLLLGSVDP
KYYDGDLISF GSIPFKDESS GYLSTGYPIV PMSRVSIANS EQEAVNLTDS SFLQPVFIHS
RYLYSYLPLS LIIQVSIQTN AVYVESLDRW LVACDIGDMG SNLIFEFGNL NISVPTVDFL
GATYNMYSNS SLRFTNGKEA CYLKMYPNYA TSFSVLGQSF IKNAYIVHDV DNSNIALAQA
ASDEAVEKAA NNSPAKKIES STIPYALPNN FTYDLAMSNS LATISSVLLN RFTATIASDG
EIFTGRSFYD TSRTTSSSEH TSFIGPPGST TKKNSGTPSA AAARIQNHFS SLTSPDKNIW
GVSLALVICG LFGLALTL
//