ID Q6CMX8_KLULA Unreviewed; 825 AA.
AC Q6CMX8;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE SubName: Full=KLLA0E16897p {ECO:0000313|EMBL:CAG99798.1};
GN ORFNames=KLLA0_E16897g {ECO:0000313|EMBL:CAG99798.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAG99798.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAG99798.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR EMBL; CR382125; CAG99798.1; -; Genomic_DNA.
DR RefSeq; XP_454711.1; XM_454711.1.
DR AlphaFoldDB; Q6CMX8; -.
DR STRING; 284590.Q6CMX8; -.
DR PaxDb; 284590-Q6CMX8; -.
DR GeneID; 2894169; -.
DR KEGG; kla:KLLA0_E16897g; -.
DR eggNOG; KOG1051; Eukaryota.
DR HOGENOM; CLU_005070_4_0_1; -.
DR InParanoid; Q6CMX8; -.
DR OMA; SKMMQGE; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598}.
FT DOMAIN 147..290
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 543..681
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 716..805
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT REGION 806..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 359..439
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 825 AA; 92666 MW; CAD810CA9E66AA84 CRC64;
MLRSAENLNR KLSRTSLLKN VKIYQPSISD VELGCTCRSF SSLVQKPNQT TVGISRGNKV
ISGLNIGARR PNISSIPPIS TAFNVASVRS YAKNYNLNLN KDQEGGESAL QQFGTNLTEL
AKQGKLDPVI GRDQEISRAI QILSRRTKNN PVLIGRAGVG KTALIDGLAQ RIVANEVPES
LKDKDLYALD LSSLVAGAKY RGEFEERLKN VLDEIDKSNG KIIVFIDEVH MLLGLGKTDG
SMDASNILKP RLARGLRCIS ATTLDEFKII EKDPALTRRF QPIILNEPSV HDTISILRGL
KEKYEVHHGV RITDSALVSA AVLSNRYIND RFLPDKAIDL VDEACAVLRL QHESKPDSIQ
AIDRAVMTMQ IELESLKKET DPVSVERREE LEKDLEVKKK ELERLTEIWE TEKSELDSIK
TAKEDLDKLR TELDICQREG DYAKASELRY AKIPELERKV ALNSKKDTEN NLLHDSVTSD
DISKVIAKMT GIPMETVLKG DKDRLLYMQN SLRERVVGQD EAIDAISDAV RLQRAGLTSE
KRPIASFMFL GPTGTGKTEL TKALAEFLFD DESNVIRFDM SEFQEKHTVS RLIGAPPGYV
LSESGGQLTE AVRRKPYAVV LFDEFEKAHP DVCKVLLQVL DEGKLTDSQG HQVDFRNTIV
VMTSNIGQDI LLHDTELGDD GKVSKKTKRS VIEAVKKNYP PEFVNRIDDL IVFNRLSKEV
LRSIVDIRLK EIQERLNDKR MTLNLTDEAK DWLTERGYDP LYGARPLNRL IHKQILNPMA
IQLLRGQLRH EETVNVVIED SKLVVKPNHD PESSELGNDK QADVE
//
