ID Q6CN16_KLULA Unreviewed; 1969 AA.
AC Q6CN16;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=KLLA0E16083p {ECO:0000313|EMBL:CAG99760.1};
GN ORFNames=KLLA0_E16083g {ECO:0000313|EMBL:CAG99760.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAG99760.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAG99760.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
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DR EMBL; CR382125; CAG99760.1; -; Genomic_DNA.
DR RefSeq; XP_454673.1; XM_454673.1.
DR STRING; 284590.Q6CN16; -.
DR PaxDb; 284590-Q6CN16; -.
DR GeneID; 2894010; -.
DR KEGG; kla:KLLA0_E16083g; -.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_000443_2_0_1; -.
DR InParanoid; Q6CN16; -.
DR OMA; TLFIAWN; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 266..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1133..1154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1262..1282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1376..1398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1455..1474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1489..1507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1519..1536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1583..1605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1668..1694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 266..647
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 694..930
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1141..1405
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1455..1704
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1928..1969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1932..1947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1948..1969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1969 AA; 226823 MW; CC0D8DD1B570FD9A CRC64;
MEGGSSRSRS RSRRNSVGAS FLDLPINSDT ASDEANAPNL DRISRLQPPV MTFSAADDDD
DKKGLIIEEE SLRSFNQDPS TDSLLNANSI SGGSNMLSIT DDDLQDFKHL QDDVKNILGG
DTSQWLRKPT SDGHSERSRS TRGSRRSSIH ETAPVARDHS SDLFTDDYEL QSIPIGTDTP
SVNAFGYHSS YQTSTGSIHS NHTRNHDDVG SAPTDTYDNT INDEEDDDPG IDRTIERHLQ
LYGKSLGFIS PDNRWRLKCA SILLKTWYKA FSMLVLTLYT IFLAHSVFFG STASGEKDFS
APSSVFSYVA TLIFNSFFTF ELIAKVIAFG FWNDSDLMNA IGKNYVSFWD VTGIRKFYRF
LETHYSSKFI HSIIPIRALF QETIDEKKSA ALKSSVTVAD FRNVKSPVDI PRAFTRSSWG
RLELLSTISA WLAYGLSIND YDDVHGLRLF RSLMAFRILK LVDLDSGLVS ILRALKYGIP
ELLNVGFMLL YFWVFFGILG VQTFKGSLKR QCVWFNPNDP SDYYQYDMQF CGGYLNAETL
EPMKYVFADN SEGPLAKGFL CPANSKCISN ANPYNGRISF DNIVNSMELV FVIMSANTFT
DLMYFTMDTD NMAACLFFIV SILCLTVWMV NLLIAVLYSS FEVVHEKYTI DKFSTQDNYL
VFNVKRLAHL IKSKSDTTKS PAWAERGIRL YEKLEWFFVL AIFTSICALA SMKSHSSDQS
AQDIFSVNQI VSCILVVETI LRLILYCKTP WKFLAKPNYV YDFIISIICA VLSFNSLRIS
LGQTSAWLLF FPISRFYRVV ILFSVTRNLW KKVLKNAIVI WNLSAFYFLF VFLASLIVLL
YFDGTLDADD MEDTPFGFYS LPNAFLTLIK IASTENWTDS LYALQRDSPT LFSALFGSVL
LILWFILSNF VVLNVFVAVI AASFDIEEED KRLLQIKHYL KVTYPERIRE FSVVPLLERI
RRKFLRKPQI DDSEDFRQFL FRGTAILSIA QNYEGFNMDL SEDKDHQFAD RNVKSSFWNR
ILWRLKALNF YKTNPFFKDP KVVFVQSDDT TPSNRKYTLK LNDWEEEKLR FLKQHPNFNN
TYFIFPPNHA LRRFCQRLVP PSYGKRTNNR VFFDDTTNKV GQKRFFYNIE KDIFVFVTFV
ATLLMVIYSC YVTPLYRMNH NKKWNWTTYF EPVFVPLFTI EFLVKTIADG FIYTPNAYCL
NPWNRIDLVV LIALWIDFFA WLLGNGELAR IIKAVSALRA LRFLTISSMA RMTFKQVMFD
GLTYIFGACA VAFSILFPYT VWGLNVFRGR LGVCNDGDLS YGECYNEFTN QVFHWDILMP
RTYADPILHL NSFSSAFRSM YEIVSLEGWT DLLQNMMSST GVGTPAELFA SPYSGIFLIL
FNFLSMVFIL NIFVSFIVGN NARMKGTAYL TLAEKSWLEV KRLLSQVCPD PMPNVFKMNA
VRRICYLWAV EKRNFYFSVL MQFMLYLHIL TLLMSKDQPY GKLPTNQNIQ FMVTTSFLLI
QEVMHIYGKS MRLYARKRWN IFRCVVVMFA FATNIYELIV DHVVVGISNA RDVFQLGIFL
LVIPQNDTLN ELMNTATASL PSIFSLVYTW FILFLVYAIA LNQVFGVTKL GPNTTGNINC
RTVTKSLILL FRCSFGEGWN YIMNDLTIEE PFCYSEADGS YTDCGSKAFA YALLMSWNII
SMYIFVNMFV SLIVEKFSYV YHREENKHSP ASQEEVRKFK VAWREIDPDG VGQFDVAYLP
KFMHSFDGPL SFKIWEGRLT VKSLVSKYMK VNPNDPYDVE IDHFGLSKEL SSIDYQKVNA
RRLDYNRFVH EIQLGNKRYN AVQFNQLMET VPLYTTYNKT ECLGIDDYVK NLYDMNKVDK
LIRNERNYDT MLMVVARWKF LLNRRGKIQL PKIMVPISSY PNGSTEDFEL EFKSPVLNTQ
ESEFMWSPGR RNNHWFEEDE SSSKENTSRT LIKDTSTKPG TTDSSSSSS
//
