ID Q6CUA9_KLULA Unreviewed; 519 AA.
AC Q6CUA9;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=KLLA0C06336p {ECO:0000313|EMBL:CAH01331.1};
GN ORFNames=KLLA0_C06336g {ECO:0000313|EMBL:CAH01331.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH01331.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH01331.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the NADH dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00005272}.
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DR EMBL; CR382123; CAH01331.1; -; Genomic_DNA.
DR RefSeq; XP_452480.1; XM_452480.1.
DR AlphaFoldDB; Q6CUA9; -.
DR STRING; 284590.Q6CUA9; -.
DR PaxDb; 284590-Q6CUA9; -.
DR GeneID; 2892105; -.
DR KEGG; kla:KLLA0_C06336g; -.
DR eggNOG; KOG2495; Eukaryota.
DR HOGENOM; CLU_021377_1_0_1; -.
DR InParanoid; Q6CUA9; -.
DR OMA; WIKLAFF; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006116; P:NADH oxidation; IEA:InterPro.
DR Gene3D; 3.50.50.100; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR045024; NDH-2.
DR PANTHER; PTHR43706; NADH DEHYDROGENASE; 1.
DR PANTHER; PTHR43706:SF10; ROTENONE-INSENSITIVE NADH-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 472..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..406
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 519 AA; 57432 MW; 6F8DF400CC0B1B2D CRC64;
MLSLSQTRNL AVRRLSSVSL AVRHSSTSTV HSAKDGSKVP AGSASFTTTK LIENNADNKP
NVVILGSGWG AISFLQHIDA KKYNVSIVSP RNYFLFTPLL PSTPVGTVDE KSIIEPVVNF
ALKKKGNVSY YEAEATSINP DRNTVTIKSV STVSQLYQPE KHLGLSQEDT AEIKYDYLLT
AVGAEPNTFG IPGVEQYGNF LKEIPHSLQI RKRFLANIEK ANLLPKGDPE RKRLLTIVVV
GGGPTGVETA GELQDYVDQD LKRFMPSIAE EVQIHLVEAL PNVLNMFEKK LTSYAQDVLS
KTNINLMLRT AVGKVEKDHL IAKTKDADGN VTEQTVPYGT LIWATGNKAR PIVTDLFKKI
TEQNASTRAL NVDEHLLVKG SNNIFAIGDN AFAGLPPTAQ VAHQQAEYLA KVFDKMAKIP
GFQQELATRK EKIDLLFEEN GFKPFKYVHL GALAYLGAEK AIANITYGKR SFYTGGGLIT
FYIWRVLYVG MILSARSRFK VIADWLKLAF FKRDCFKEL
//
