ID Q6CUF0_KLULA Unreviewed; 1605 AA.
AC Q6CUF0;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=KLLA0C05368p {ECO:0000313|EMBL:CAH01290.1};
GN ORFNames=KLLA0_C05368g {ECO:0000313|EMBL:CAH01290.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH01290.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH01290.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR EMBL; CR382123; CAH01290.1; -; Genomic_DNA.
DR RefSeq; XP_452439.1; XM_452439.1.
DR STRING; 284590.Q6CUF0; -.
DR PaxDb; 284590-Q6CUF0; -.
DR GeneID; 2892355; -.
DR KEGG; kla:KLLA0_C05368g; -.
DR eggNOG; KOG1001; Eukaryota.
DR HOGENOM; CLU_244107_0_0_1; -.
DR InParanoid; Q6CUF0; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18008; DEXDc_SHPRH-like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45626:SF24; ATP-DEPENDENT HELICASE ULS1; 1.
DR PANTHER; PTHR45626; TRANSCRIPTION TERMINATION FACTOR 2-RELATED; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 932..1137
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1313..1371
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1432..1588
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT COILED 143..198
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1605 AA; 184434 MW; B306BEE02258AB65 CRC64;
MTENGAEIPV VNLTLDAEEE EENEVVSELK RQETPKLFVK REIDEIEAEH LQPLVKHFKP
MEQDSQVIVV SSEEEADVKP AEGAHVALQH LQERLLVLTK KLRAKKSMTD VLTNKLARRK
DAEDTLQVKY RSLLNLYGED PNMPSQRKLL TDLRQQIRAA EERTVATRTK LHSVKRDHHD
LENEIKQLYE RIRAISSHNG KEMSLQLQSV SKDIIKDVRK HNLFVETINK VKELLRNTSR
SEDNKIYINT LCDRLLAFES EIFYEQPSSV FLKATIYQIL TELTSQGIKM PYIFQRFQEL
KLYDEDLPKS EESLSTDSKF KSHIDQVFSL ADKIHRPDKE KHQIKHYASI VLDGYRNRSQ
YPLQHPGKYN KITHALLRLV QLGVRIPFVL EEMKKLHYNI NSAIDSTKVF QEIHAVKSSI
LEKSLSSDRA SKLFKDLDLL IGFLEFTLEG EEVYDPEIVK NIFKLMVHIE RLNINIPYTK
EAMHKLGLNW DDFIDTEYFL QSITKMKRRL HELKSSRSPA DMSRILQSLD CLVFFIEKYH
EDKQYKVPTM HSKEREEVCH SAHILHSSGI LLLYCYESLT KLGFDWQYYP EESLKVIELA
KDMLQKDSSK TIHEKANILT LIQTLEKGII RAMDMSTFSE MKIESFRLTL STLQRTGCKM
PSVELTYQSI MKGTYLNCLL NAERQAALVD NARDSQSSTS HSLSSGLKYE KDDKALIGNP
PYESKKSTSK LEGHSQLLSL RKLQDEIEEA ILTLSTNHSL DKMAQDTIVS ALSNILSLLK
ISEEFNSTTV PSMWRSTVQM SIDVLDRFLY IGTIPGVLDR LFQLGFSIPE QYANDDDLAV
IGGKTIKNEE FVTYDSDEDD DIDEVIENYK TRIDHSLRMT NIYNTADASS LRDLLEGLKE
IETEVEGEDL TPNELTVNLL KHQRQGLRWL VSMEKSSKRG GLLADDMGLG KTVQSLALLM
ANKPEPKSAI KTTLVVAPVA VLRVWKDEVA VKIKKDVNVK VVIFGGGENN SSKFRSWKDL
AEYDIVLVSY QTLASEFKKH WPLSWKNGEH QPDVHAVDLK LMNQVKSSDE YFSPFYRNDS
EFYRVILDEA QNIKNKKTQA AKACCTISST FRWALSGTPI QNNIGELYSL IRFLRIPPYN
KEAKFHSDIG AVLNTKKPYD YNDSERQRAM KKVQVLLRAI MLRRTKTSQI DGKPILQLPE
KHLKESANKL EGDELEFYQA LESKSRDKAK KMLESKQKQG AYSSILTLLL RLRQACLHSE
LVKIGESNAK SSKIINGKDF EKDWRPLYFV SKRMGQNQAT LNAVNACLDD MTCPVCMEQM
DIDSMLVLNS CGHCLCAQCF EPYVDNAKLE PTASFGPKGT NSVNIPCLVC RKMNNDKEAI
SYQLFDQVNN LNYSIDDLRL EYDKMVAEQK ARLKNGYTID YKSLKESKKV EMCLDIIKKV
TDSNTDEKLV IFSQFTMFFE ILGHFIKKNL GLNFLRYDGS MSSSQRSACI ESFYQDNNYR
VMLISMKAGN SGLTLTCANH VILADPFWNP FVEEQAMDRC HRISQEREVY VHRLLIKMSV
EDRIVELQNK KKTLVNLAMD PTQIREVNKL GRKELGFLFG LNSLD
//
