ID   Q6CZA1_PECAS            Unreviewed;       386 AA.
AC   Q6CZA1;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:CAG77149.1};
DE            EC=2.5.1.48 {ECO:0000313|EMBL:CAG77149.1};
GN   Name=metB {ECO:0000313|EMBL:CAG77149.1};
GN   OrderedLocusNames=ECA4252 {ECO:0000313|EMBL:CAG77149.1};
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491 {ECO:0000313|EMBL:CAG77149.1, ECO:0000313|Proteomes:UP000007966};
RN   [1] {ECO:0000313|EMBL:CAG77149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SCRI1043 {ECO:0000313|EMBL:CAG77149.1};
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M., Hyman L.J., Holeva M.C.,
RA   Thomson N.R., Bentley S.D., Churcher C., Mungall K., Atkin R., Bason N.,
RA   Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z.,
RA   Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C.,
RA   Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C.,
RA   Birch P.R.J., Barrell B.G., Parkhill J., Toth I.K.;
RT   "The genome sequence of the enterobacterial phytopathogen Erwinia
RT   carotovora subsp. atroseptica SCRI1043 and functional genomic
RT   identification of novel virulence factors.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; BX950851; CAG77149.1; -; Genomic_DNA.
DR   RefSeq; WP_005973357.1; NC_004547.2.
DR   AlphaFoldDB; Q6CZA1; -.
DR   STRING; 218491.ECA4252; -.
DR   GeneID; 57210924; -.
DR   KEGG; eca:ECA4252; -.
DR   PATRIC; fig|218491.5.peg.4329; -.
DR   eggNOG; COG0626; Bacteria.
DR   HOGENOM; CLU_018986_2_0_6; -.
DR   OrthoDB; 9805807at2; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR011821; O_succ_thio_ly.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR02080; O_succ_thio_ly; 1.
DR   PANTHER; PTHR11808:SF75; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007966};
KW   Transferase {ECO:0000313|EMBL:CAG77149.1}.
FT   MOD_RES         198
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   386 AA;  41356 MW;  CD6E797DE39E9841 CRC64;
     MTRKQATIAV RSGLNDDEQY GCVVPPIHLS STYNFTGFNQ PRAHDYSRRG NPTRDVVQRA
     LAELEGGAGA VMTSSGMSAI MLVCTVFLRP GDLLVAPHDC YGGSYRLFDS LSKRGAFRVK
     FVDQGDTHAL NAALAEKPKL VLVESPSNPL LRVVDIAAIC QAAREAGAVS VVDNTFLSPA
     LQKPLELGAD LVVHSCTKYL NGHSDVVAGA VIAKDVDTIT ELAWWANNIG VTGAAFDSYL
     LLRGLRTLSP RMAAAQRNAQ QVVEFLQTQP LVKALYHPSL PNNPGHDIAR RQQSGFGAML
     SFELDGDEDT LRRFLASLEL FTLAESLGGV ESLISHAATM THAGMAPEAR AAAGISETLL
     RISTGIEDGD DLVADLDRAF QAAAKR
//