ID Q6DCL4_XENLA Unreviewed; 781 AA.
AC Q6DCL4;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=tnfaip3.S {ECO:0000313|RefSeq:NP_001087109.1,
GN ECO:0000313|Xenbase:XB-GENE-6254829};
GN Synonyms=a20 {ECO:0000313|RefSeq:NP_001087109.1}, otud7c
GN {ECO:0000313|RefSeq:NP_001087109.1}, tnfa1p2
GN {ECO:0000313|RefSeq:NP_001087109.1}, tnfaip3
GN {ECO:0000313|RefSeq:NP_001087109.1,
GN ECO:0000313|Xenbase:XB-GENE-6254829}, tnfaip3-prov
GN {ECO:0000313|EMBL:AAH77994.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH77994.1};
RN [1] {ECO:0000313|RefSeq:NP_001087109.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH77994.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen {ECO:0000313|EMBL:AAH77994.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001087109.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the peptidase C64 family.
CC {ECO:0000256|ARBA:ARBA00005865}.
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DR EMBL; BC077994; AAH77994.1; -; mRNA.
DR RefSeq; NP_001087109.1; NM_001093640.1.
DR MEROPS; C64.003; -.
DR DNASU; 446998; -.
DR GeneID; 446998; -.
DR KEGG; xla:446998; -.
DR AGR; Xenbase:XB-GENE-6254829; -.
DR CTD; 446998; -.
DR Xenbase; XB-GENE-6254829; tnfaip3.S.
DR OrthoDB; 2909231at2759; -.
DR Proteomes; UP000186698; Chromosome 5S.
DR Bgee; 446998; Expressed in spleen and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd22766; OTU_TNFAIP3; 1.
DR Gene3D; 3.90.70.80; -; 1.
DR Gene3D; 4.10.240.30; -; 3.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR002653; Znf_A20.
DR PANTHER; PTHR13367:SF3; TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3; 1.
DR PANTHER; PTHR13367; UBIQUITIN THIOESTERASE; 1.
DR Pfam; PF02338; OTU; 1.
DR Pfam; PF01754; zf-A20; 3.
DR SMART; SM00259; ZnF_A20; 7.
DR PROSITE; PS50802; OTU; 1.
DR PROSITE; PS51036; ZF_A20; 4.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 93..264
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT DOMAIN 378..413
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT DOMAIN 459..494
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT DOMAIN 586..621
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT DOMAIN 737..771
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
SQ SEQUENCE 781 AA; 89285 MW; 0A74F626D0E2F26E CRC64;
MASQQGLPQD LYMSNMLKAV KIRKMAQKDI VRHSSGIIHH FETMHRYTIE LFMICHFCVQ
FQKILQKSLV DRAMQIALES HKKLNACREV KKLIPLKAHG DGNCLMHATS LYMWGVQDTE
LVLRKTLYNV LRTTDTRNFK FRWQLECVKS MEFTETGLRY DTKNWDEEWD QLVKMASTET
SQGQNGLQYN CLEEIHIFVL SNILRRPVII LADNVMRSLE SGSSFSPLNV SGIYLPLHWP
AKECYKYPVV LGYDSQHFAP LVTMKDSGPE IRAVPLVVSD DENFEDMKVH FLTDHEEKSK
EKLIKEYLSV LEIPVQCWEN GTTHLIKTAR LDEDNLPKEL HLVDDFVELV QHEYTRWQET
DQNKSRRTRL ETLLPQLSLV EVKCETPNCP FYVSVNTQPY CHECYQHNQR VTNRQKQKSE
SVEHSSEYMV PFEQIVSGES VTGHVSTLAT APSLFLYSET TAMKCKTPDC PFTLNIQLNG
LCEHCYNAKH HFPVNAVGMS SSTDIKCNLC FQDTNRTFNG ICSACFKRTT EHFTKSSVPL
KANETADPVD LSRSLIPLSD LEGGHCDSQE CIPSSQSLVL YNIEKKTENR KCRKTGCPFF
GTVQNEGFCT LCFYAFQENN ASTRRSPKLL PLVNQSSATT FNNLPCCLGR ECSSLGSTLF
EGYCQKCFLV AQRRHQACSG ETEISGQNRR KKHSTSGTQV KLCARNICSN CLICRSDEIC
DQCRPKPGSH RITVENSPKQ RCCAPGCDHY GNNKCKGFCN ECFQFKHTYW EGLERTGSND
M
//
