ID Q6DJ90_XENTR Unreviewed; 719 AA.
AC Q6DJ90; A0A6I8QK84;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Serine protease 36 {ECO:0000313|Ensembl:ENSXETP00000068975, ECO:0000313|RefSeq:NP_001005710.1};
DE SubName: Full=Transmembrane serine protease 9 {ECO:0000313|EMBL:AAH75293.1};
GN Name=prss36 {ECO:0000313|Ensembl:ENSXETP00000068975,
GN ECO:0000313|RefSeq:NP_001005710.1,
GN ECO:0000313|Xenbase:XB-GENE-5892976};
GN Synonyms=tmprss9 {ECO:0000313|EMBL:AAH75293.1,
GN ECO:0000313|RefSeq:NP_001005710.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH75293.1};
RN [1] {ECO:0000313|RefSeq:NP_001005710.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH75293.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH75293.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000068975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000068975};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000068975}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001005710.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC075293; AAH75293.1; -; mRNA.
DR RefSeq; NP_001005710.1; NM_001005710.1.
DR MEROPS; S01.048; -.
DR Ensembl; ENSXETT00000088388; ENSXETP00000068975; ENSXETG00000006294.
DR GeneID; 448231; -.
DR KEGG; xtr:448231; -.
DR AGR; Xenbase:XB-GENE-5892976; -.
DR CTD; 146547; -.
DR Xenbase; XB-GENE-5892976; prss36.
DR OMA; KNATSCW; -.
DR OrthoDB; 4629979at2759; -.
DR Reactome; R-XTR-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR Proteomes; UP000008143; Chromosome 9.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 4.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24253:SF144; BRAIN-SPECIFIC SERINE PROTEASE 4; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00089; Trypsin; 2.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 2.
DR PROSITE; PS00134; TRYPSIN_HIS; 2.
DR PROSITE; PS00135; TRYPSIN_SER; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000313|EMBL:AAH75293.1};
KW Protease {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:AAH75293.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001005710.1};
KW Transmembrane {ECO:0000313|EMBL:AAH75293.1}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..719
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001005710.1"
FT /id="PRO_5033205998"
FT DOMAIN 37..279
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 385..627
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 285..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 76099 MW; 906346A21D8834C6 CRC64;
MELTETFLLL LAFVSPTIVS TTPAPPSCGS PLVSSRIVGG TDAREGAWPW QVSLRYRGSH
ICGGSVIGTQ WILTAAHCFG NSQSPSDYEV RLGAYRLAET SPNEITAKVD RIIMHPQYDE
LTYFGDIALI RLTSPIDYTA YILPVCLPSA SNSFTDGMEC WVTGWGKTAF NVNLPFPGTL
QEVMTPLINR TRCDQMYHID SPVSASSEII PSDQICSGYS DGGKDSCKGD SGGALVCKIQ
RVWYQIGIVS WGDGCAIANR PGVYTLVPAY QSWLSSYNAT ENTINVDNSG TTTAATTTRR
ATVTTASSAS SSASSSPASS SPASSPASSP ASSSPTSSSP ASSSPTSSSP ASSPASSSST
FVSPTILSTT PAPPACGSPL VSSRIVGGTD AREGAWPWQV SLRYRGSHIC GGSVIGTQWI
LTAAHCFENS QFPSDYEVRL GTYRLAQTSP NEITYTVDRI IVNSQFDSST LFGDIALIRL
TSPITYTKYI LPVCLPSTSN SFTDGMECWV TGWGTISLYV NLPYPKTLQE VMTPLINRTR
CDQMYHIDSP VSASSEIIPS DQICSGYSAG GKDSCKGDSG GPLVCKLQGI WYQIGIVSWG
EGCAIAKRPG VYTLVPAYYS WVIAEENTVN VDSIGTTNSL PTTTTTGTTT STTTTTGTTT
TGTTTSTTTT TGTTTTTTGT TTTTQGYNRS SPSSLNKSVH LIGACSFLLI WLIVVAEGQ
//
