ID Q6DKE8_XENLA Unreviewed; 584 AA.
AC Q6DKE8;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=APOBEC1 complementation factor L homeolog {ECO:0000313|RefSeq:NP_001086049.1};
DE SubName: Full=MGC81834 protein {ECO:0000313|EMBL:AAH74127.1};
GN Name=a1cf.L {ECO:0000313|RefSeq:NP_001086049.1,
GN ECO:0000313|Xenbase:XB-GENE-952966};
GN Synonyms=a1cf {ECO:0000313|RefSeq:NP_001086049.1,
GN ECO:0000313|Xenbase:XB-GENE-952966}, acf
GN {ECO:0000313|RefSeq:NP_001086049.1}, acf64
GN {ECO:0000313|RefSeq:NP_001086049.1}, acf65
GN {ECO:0000313|RefSeq:NP_001086049.1}, apobec1cf
GN {ECO:0000313|RefSeq:NP_001086049.1}, asp
GN {ECO:0000313|RefSeq:NP_001086049.1}, MGC81834
GN {ECO:0000313|EMBL:AAH74127.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH74127.1};
RN [1] {ECO:0000313|RefSeq:NP_001086049.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH74127.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAH74127.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001086049.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; BC074127; AAH74127.1; -; mRNA.
DR RefSeq; NP_001086049.1; NM_001092580.1.
DR GeneID; 444478; -.
DR KEGG; xla:444478; -.
DR AGR; Xenbase:XB-GENE-952966; -.
DR CTD; 444478; -.
DR Xenbase; XB-GENE-952966; a1cf.L.
DR OrthoDB; 3184171at2759; -.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 444478; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd19900; DSRM_A1CF; 1.
DR CDD; cd12486; RRM1_ACF; 1.
DR CDD; cd12490; RRM2_ACF; 1.
DR CDD; cd12498; RRM3_ACF; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR044461; A1CF_DSRM.
DR InterPro; IPR034538; ACF_RRM1.
DR InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR PANTHER; PTHR21245:SF8; APOBEC1 COMPLEMENTATION FACTOR; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR Pfam; PF14709; DND1_DSRM; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 56..134
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 136..218
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 231..303
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 64266 MW; 97ECA7F5272D5690 CRC64;
MESNQKSGDG MAGTQKEASL RTLIQRTGYS LTQENGQRRY GGPPPGWDGP PPERGCEIFI
GKLPRDLFED ELIPLCEKTG KIYEMRMMMD FNGNNRGYAF VTFTNRQDAR DAIKQLNNYE
IRNGRLLGVC ASVDNCRLFV GGIPKTKRRE EILAEMRKVT DGVLDVIVYP SAADKAKNRG
FAFVEYESHR AAAMARRKLL PGRIQLWGHP IAVDWAEPEV EVDEDTMSSV KILYVRNLML
TTAEETIEKE FSSVKPGSVE RVKKIRDYAF VHFRNRADAV DAMNVLNGKI IDGSPIEVTL
AKPVDKESYV RYTRGTGGRG AAIQGEYTYT IGHVYDPTTA YLGAPVFYAP PAYTAAIPSI
QFPPVKGYVN NRSLVRPPSV RVGAAGVRGL GGRGYLAYTG LGRGYTGFQM KGDKRADDKL
YDILPGMEIT PMTTVALKPQ GIKLGPQILE EICQKNNWGQ PVYQLHSAIG PDQRQLFLYK
VTIPALASQN PTIYPFTPPK LCISVDEAKT YAADYTLQTL GIPTETAEHP TAFAGYTIAN
TPAAVAATQL KQAVALGQDL AAYATYETYP AFALAARGDG YGAF
//
