ID Q6DVF3_ORYLA Unreviewed; 765 AA.
AC Q6DVF3;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 95.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:AAT64912.1};
RN [1] {ECO:0000313|EMBL:AAT64912.1}
RP NUCLEOTIDE SEQUENCE.
RA Liu R., Hong Y.;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY639947; AAT64912.1; -; mRNA.
DR AlphaFoldDB; Q6DVF3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10374; SH2_STAT3; 1.
DR CDD; cd16853; STAT3_CCD; 1.
DR CDD; cd16847; STAT3_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR035855; STAT3_SH2.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF2; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 581..671
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 140..167
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 765 AA; 87566 MW; F5D01408748EC703 CRC64;
MAQWNQLQQL ETRYLEQLYH LYSDSFPMEL RQFLAPWIES QDWAYAANKE SHATLVFHNL
LGEIDQQYSR FLQENNVLYQ HNLRRIKQHL QSKYLEKPME IARIVARCLW EEQRLLQTAT
STSQDGSAAH PTGTVVTEKQ QILEHNLQDI RKRVQDMEQK MKMLENLQDD FDFNYKTLKS
QGELNQDLNG NSQAAATRQK MAQLEQMLSA LDQLRRQIVT EMGGLLTAMD YVQKNLTDEE
LADWKRRQQI ACIGGPPNIC LDRLETWITS LAESQLQIRQ QIKKLEELQQ KVSYKGDPII
QHRPALEEKI VDLFRNLMKS AFVVERQPCM PMHPDRPLVI KTGVQFTNKV RLLVKFPELN
YQLKIKVCID KESGDVAAIR GSRKFNILGT NTKVMNMGES NNGSLSAEFK HLTLREQRCG
NGGRTNSDAS LIVTEELHLI TFETEVYHQG LKIDLETHSL PVVVISNICQ MPNAWASILW
YNMLTNHPKN VNFFTKPPVG TWDQVAEVLS WQFSSTTKRG LTIEQLTTLA EKLLGPSVNY
SGCQITWAKF CKENMAGKGF SFWVWLDNII DLVKKYILAL WNEGYIMGFI SKERERAILS
PKPPGTFLLR FSESSKEGGI TFTWVEKDIS GKTQIQSVEP YTKQQLNSMS FADIIMGYKI
MDATNILVSP LVYLYPDIPK EEAFGKYCRP EAAHEPEAGG DSASITQPYL KTKFICVTPT
NSGNTSDLFP MMSPRTLDSL MHNEPEAHSG HLDSITLDMD VASPM
//
