ID Q6E7F5_ECOLX Unreviewed; 253 AA.
AC Q6E7F5;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00019048};
DE EC=2.7.7.9 {ECO:0000256|ARBA:ARBA00012415};
DE AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00031455};
DE AltName: Full=UDP-glucose pyrophosphorylase {ECO:0000256|ARBA:ARBA00031959};
DE AltName: Full=Uridine diphosphoglucose pyrophosphorylase {ECO:0000256|ARBA:ARBA00032341};
DE Flags: Fragment;
GN Name=galF {ECO:0000313|EMBL:AAS99158.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AAS99158.1};
RN [1] {ECO:0000313|EMBL:AAS99158.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15231783; DOI=10.1128/JB.186.14.4510-4519.2004;
RA Feng L., Senchenkova S.N., Yang J., Shashkov A.S., Tao J., Guo H.,
RA Cheng J., Ren Y., Knirel Y.A., Reeves P.R., Wang L.;
RT "Synthesis of the heteropolysaccharide O antigen of Escherichia coli O52
RT requires an ABC transporter: structural and genetic evidence.";
RL J. Bacteriol. 186:4510-4519(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000872};
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family.
CC {ECO:0000256|ARBA:ARBA00006890}.
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DR EMBL; AY528413; AAS99158.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6E7F5; -.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43197:SF2; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
FT DOMAIN 2..232
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAS99158.1"
SQ SEQUENCE 253 AA; 27830 MW; 17C0C60E58FB7D32 CRC64;
IVAAGIKEIV LVTHASKNSV ENHFDTSYEL EALLEQRVKR QLLAEVQSIC PPGVTIMNVR
QAQPLGLGHS ILCAHPIVGD NPFVVVLPDI VLDNASADPL RYNLAAMVAR FNETGRSQVL
AKRMPGDLSE YSVIKTKEPL DVEGKVSRIV DFIEKPDQPQ TLESDLMAVG RYVLSADIWP
ELAKTVPGAW GRIQLTDAIA ELANKQSVDA MLMTGESYDC GKKMGYMQAF VQYGLRNLKE
GAKIRKSIEK LLS
//
