ID Q6F5N9_BVDV Unreviewed; 147 AA.
AC Q6F5N9;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
GN Name=NS3 {ECO:0000313|EMBL:BAD27053.1};
OS Bovine viral diarrhea virus (BVDV) (Mucosal disease virus).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Pestivirus; Pestivirus bovis.
OX NCBI_TaxID=11099 {ECO:0000313|EMBL:BAD27053.1};
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1] {ECO:0000313|EMBL:BAD27053.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IS10 NCP/98 {ECO:0000313|EMBL:BAD27053.1};
RX PubMed=14749175; DOI=10.1016/j.virusres.2003.10.006;
RA Nagai M., Hayashi M., Sugita S., Sakoda Y., Mori M., Murakami T., Ozawa T.,
RA Yamada N., Akashi H.;
RT "Phylogenetic analysis of bovine viral diarrhea viruses using five
RT different genetic regions.";
RL Virus Res. 99:103-113(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-
CC diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00001491};
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DR EMBL; AB105724; BAD27053.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011492; Flavi_DEAD.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07652; Flavi_DEAD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Virion {ECO:0000256|ARBA:ARBA00022804};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1..134
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAD27053.1"
FT NON_TER 147
FT /evidence="ECO:0000313|EMBL:BAD27053.1"
SQ SEQUENCE 147 AA; 16487 MW; E596B8DFBC4C4659 CRC64;
KAVIEEIGRH KRVLVLIPLR AAAESVYQYM RLKHPSISFN LRIGDMKEGD MATGITYASY
GYFCQMPQPK LRAAMVEYSY IFLDEYHCAT PEQLAVIGKI HRFSESIRVV AMTATPAGSV
TTTGQKHPIE EFIAPEVMKG EDLGSQF
//
