ID Q6FN17_CANGA Unreviewed; 527 AA.
AC Q6FN17;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN Name=HFD1 {ECO:0000313|CGD:CAL0133859};
GN OrderedLocusNames=CAGL0K03509g {ECO:0000313|CGD:CAL0133859,
GN ECO:0000313|EMBL:CAG61338.1};
OS Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
OS NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX NCBI_TaxID=284593 {ECO:0000313|EMBL:CAG61338.1, ECO:0000313|Proteomes:UP000002428};
RN [1] {ECO:0000313|EMBL:CAG61338.1, ECO:0000313|Proteomes:UP000002428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC {ECO:0000313|Proteomes:UP000002428};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CR380957; CAG61338.1; -; Genomic_DNA.
DR RefSeq; XP_448377.1; XM_448377.1.
DR AlphaFoldDB; Q6FN17; -.
DR STRING; 284593.Q6FN17; -.
DR EnsemblFungi; CAGL0K03509g-T; CAGL0K03509g-T-p1; CAGL0K03509g.
DR GeneID; 2890178; -.
DR KEGG; cgr:CAGL0K03509g; -.
DR CGD; CAL0133859; HFD1.
DR VEuPathDB; FungiDB:CAGL0K03509g; -.
DR eggNOG; KOG2456; Eukaryota.
DR HOGENOM; CLU_005391_3_1_1; -.
DR InParanoid; Q6FN17; -.
DR OMA; EPCIQGQ; -.
DR Proteomes; UP000002428; Chromosome K.
DR GO; GO:0005811; C:lipid droplet; IEA:EnsemblFungi.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:EnsemblFungi.
DR GO; GO:0018484; F:4-hydroxybenzaldehyde dehydrogenase activity; IEA:EnsemblFungi.
DR GO; GO:0047770; F:carboxylate reductase activity; IEA:EnsemblFungi.
DR GO; GO:0046185; P:aldehyde catabolic process; IEA:EnsemblFungi.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:EnsemblFungi.
DR GO; GO:0032180; P:ubiquinone biosynthetic process from tyrosine; IEA:EnsemblFungi.
DR CDD; cd07135; ALDH_F14-YMR110C; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR Pfam; PF00171; Aldedh; 1.
DR PIRSF; PIRSF036492; ALDH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000002428}.
FT DOMAIN 33..457
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 232
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT ECO:0000256|PROSITE-ProRule:PRU10007"
FT ACT_SITE 269
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ SEQUENCE 527 AA; 59337 MW; 3D036832ED9AF20B CRC64;
MAEILNYTEL SEIDAKISIS RNYFQQNRKE LANQKNVRSA DNKQRQFWLK KLYWSVKDHE
EQILEALEKD FHRSRQESIS LEYVKLLGDI LHLIEGIPKW NKPKKVRDNS APFMFGNINI
EKISRGNVLV ISPFNFPVLL ALAPVACALS AGNTVILKPS EMTPHCALVL EDIVKSCQLP
EGVLQIVQGG VEQTTKLINS ESLDMIFYTG SPRVGSIVAQ AAAKNLVPCV LELGGKSPTF
ITGSLQKKNL ETALKRIFFG AFGNAGQICV SPDYLLVHES IYDDVVKESG KVMKELYPDL
NEHTEYTHMI HKASYDKTLE KLQKTKGRKV SAADVKIDNT SGKLMIPPTI VFDSDWDDAL
MEEENFAPVL PVIKYTDIDA TIDKILSKHD TPLVQYIFSE KQKEIDHILA RLRSGDCIIC
DTTIHVGIKD APFGGIGQSG YGNYGGVYGF DAFSHERIVL KQPFWVDFLL KLRYPPFTAK
KVKLLKLATE RQPWFDREGN DHRSYKLIAM FSVTCALLAV GVKSFFV
//
