ID Q6FWR8_CANGA Unreviewed; 446 AA.
AC Q6FWR8;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 92.
DE SubName: Full=Candida glabrata strain CBS138 chromosome C complete sequence {ECO:0000313|EMBL:CAG58232.1};
GN Name=LYS9 {ECO:0000313|CGD:CAL0127518};
GN OrderedLocusNames=CAGL0C03443g {ECO:0000313|CGD:CAL0127518,
GN ECO:0000313|EMBL:CAG58232.1};
OS Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
OS NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX NCBI_TaxID=284593 {ECO:0000313|EMBL:CAG58232.1, ECO:0000313|Proteomes:UP000002428};
RN [1] {ECO:0000313|EMBL:CAG58232.1, ECO:0000313|Proteomes:UP000002428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC {ECO:0000313|Proteomes:UP000002428};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
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DR EMBL; CR380949; CAG58232.1; -; Genomic_DNA.
DR RefSeq; XP_445326.1; XM_445326.1.
DR AlphaFoldDB; Q6FWR8; -.
DR STRING; 284593.Q6FWR8; -.
DR EnsemblFungi; CAGL0C03443g-T; CAGL0C03443g-T-p1; CAGL0C03443g.
DR GeneID; 2886722; -.
DR KEGG; cgr:CAGL0C03443g; -.
DR CGD; CAL0127518; LYS9.
DR VEuPathDB; FungiDB:CAGL0C03443g; -.
DR eggNOG; KOG0172; Eukaryota.
DR HOGENOM; CLU_016207_3_1_1; -.
DR InParanoid; Q6FWR8; -.
DR OMA; WNYKFTW; -.
DR Proteomes; UP000002428; Chromosome C.
DR GO; GO:0004755; F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity; IEA:EnsemblFungi.
DR GO; GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IEA:EnsemblFungi.
DR Gene3D; 1.10.1870.10; Domain 3, Saccharopine reductase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032095; Sacchrp_dh-like_C.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR11133:SF25; ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11133; SACCHAROPINE DEHYDROGENASE; 1.
DR Pfam; PF16653; Sacchrp_dh_C; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002428}.
FT DOMAIN 5..119
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
FT DOMAIN 123..437
FT /note="Saccharopine dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16653"
SQ SEQUENCE 446 AA; 48933 MW; 202C942826B86E2B CRC64;
MTKRVLLLGS GFVAQPVIDT LAATEGIEVT VACRTLANAK QLASASGSDA ISLDVTDDSA
LDAALGQHDL VISLIPYTFH PNVVRSAIRL KKDVVTSSYI SPALRELEPE INKAGITVMN
EIGLDPGIDH LYAVKTIDEV HRAGGKIKSF LSYCGGLPAP EDSDNPLGYK FSWSSRGVLL
ALRNSAKYWK DGKIETISSE DLMASAKPYF IYPGYAFVCY PNRDSTLFKE LYHIPEADTV
IRGTLRYQGF PEFVKALVDM GMLKDDENAI FSSAIPWNDA LKQYLGAKST SREDLVASID
SKTNWKSQED RDRILSGFAW LGLFSDTKIT PRGNALDTLC ARLEELMQYE DGERDMVALQ
HKFGIEWADG TTEVRTSTMI DYGKVGGYSS MAATVGYPVA IATKFVLNGT IKGPGLLAPY
SPEINDPIMK ELKDKYGLYL KEKTIA
//
