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Database: UniProt
Entry: Q6FY64_CANGA
LinkDB: Q6FY64_CANGA
Original site: Q6FY64_CANGA 
ID   Q6FY64_CANGA            Unreviewed;      1652 AA.
AC   Q6FY64;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   29-OCT-2014, entry version 67.
DE   RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN   OrderedLocusNames=CAGL0A03718g {ECO:0000313|EMBL:CAG57822.1};
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593 {ECO:0000313|Proteomes:UP000002428};
RN   [1] {ECO:0000313|Proteomes:UP000002428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC   {ECO:0000313|Proteomes:UP000002428};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC       coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC       {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR002290}.
CC   -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC       {ECO:0000256|PIRNR:PIRNR002290}.
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DR   EMBL; CR380947; CAG57822.1; -; Genomic_DNA.
DR   RefSeq; XP_444929.1; XM_444929.1.
DR   ProteinModelPortal; Q6FY64; -.
DR   SMR; Q6FY64; 1210-1522.
DR   GeneID; 2886384; -.
DR   KEGG; cgr:CAGL0A03718g; -.
DR   HOGENOM; HOG000188877; -.
DR   InParanoid; Q6FY64; -.
DR   KO; K04646; -.
DR   OMA; WKWFSEK; -.
DR   OrthoDB; EOG7V4B6Q; -.
DR   GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR   GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 3.
DR   Gene3D; 2.130.10.110; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR016025; Clathrin_H-chain_link/propller.
DR   InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR   InterPro; IPR001473; Clathrin_H-chain_propeller_N.
DR   InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR   InterPro; IPR016341; Clathrin_heavy_chain.
DR   InterPro; IPR011990; TPR-like_helical_dom.
DR   Pfam; PF00637; Clathrin; 7.
DR   Pfam; PF09268; Clathrin-link; 1.
DR   Pfam; PF01394; Clathrin_propel; 1.
DR   PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR   SMART; SM00299; CLH; 7.
DR   SUPFAM; SSF48371; SSF48371; 6.
DR   SUPFAM; SSF50989; SSF50989; 1.
DR   PROSITE; PS50236; CHCR; 7.
PE   3: Inferred from homology;
KW   Coated pit {ECO:0000256|PIRNR:PIRNR002290};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002428};
KW   Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR002290};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002290};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002428}.
SQ   SEQUENCE   1652 AA;  187448 MW;  4C031F6FF82EC710 CRC64;
     MSDLPIEFTE LTDLTALGIS PQSLDFRSTT FESDHYVTVR ETVDGANSVA IVDLANGNQV
     TRKNMGGDSA IMHPSQNVIS VRANGTIVQI FNLETKSKLK SFTLDEPVIF WKWLTENTLG
     FVTARSILTC NVFDGNVSAK PQVLTQRHQS LNNTQIINFI SNEKEDWFAV IGILQENGRI
     AGKIQLYSKQ RNISQAVDGH VAIFTKILLE GNGSAPVQVF VTGNRNVQTG NGELRIIEID
     HDASLAVQYQ KKTTDIFFPP DATNDFPLSV QVSEKYGIIY ILTKYGFIHL YELETGTNLF
     VNRITAESVF TSTSYNQKNG IACINKKGQV LAVEIDTTQI VPYILNKLAN VSLALTVATR
     GGLPGADDLF SKQFESLLNQ GDYQNAAKVA ASSTSLRNQN TINRLKNLQA APGAISPILL
     YFSTLLDKGK LNKEETIELA RPVLQQDRKQ LFEKWLKEDK LECSEELGDI VKPFDTTLAL
     ACYLRANAHA KVISCLAELQ QFEKIIPYCQ KVSYQPNFLV LLSQLIRTSP DRASEFAISL
     LQNPETASQV DIEKLADLFF SQNHIQQGTS LLLDALKGDT PDQGHLQTRV LEVNLMNAPQ
     VADAILGNNI FSHYDKPTIA SLAEKAGLYQ RALENYTDLK DTKRCIVHTS SLPVDWLISY
     FGKLNVEQSL ACLRALMDDN LQGNIQIVIQ VATKYSDLIG SSTLIKLFEE YRATEGLYYY
     LASLVNLTED KDVVYKYIEA AAKMKQYKEI ERIVRDNNVY DAERVKNFLK EANLEDQLPL
     IIVCDRHNFV HELILYLYKA QNMNYIETYV TQVNPSKTPQ VVGALLDMDC DEKFIQNLLQ
     SVIGQVPIND LTEEVEKRNR LKLLLPYLEQ TLSQGTQEQA VYNALAKIYI DSNNAPEKFL
     KENDQYDTLD VGRYCEKRDP YLAYIAYDKG SNDDDLIRIT NENTMYKYQA RYLLKRSDPE
     LWNKVLDSEN IHRRQLIDSV ISVGIPELKD PEPVSLTVQA FMTNGLKLEL IELLEKIILE
     PSPFNENTAL QGLLMLSAIK YEPTKVSGYI EKLENYDADE IAQLCVEHGL NEEAFEIYDK
     HEMNSKALKV LIEDIMSLDR GYTYADKINS SELWSQLGTA QLDGLRIPDA IDSYIKANDP
     SNYENVIDLA EQAEKFEELI PYLLMARDTL KASKIDNALV LSYAQLNKLH EIENLLAGSN
     SANLEEVGDK LLDSKNYKAA KLCYSSVSNY SKLASTLVYL GDYQTAVDTA RKASNIKVWK
     LVNNACIDKK EFRLAQICGL NLIIHAEELD ELVEKYESNG YFEELISLFE AGLGLERAHM
     GMFTELAILY AKYDTSKTYD HIKLFWSRIN IPKVIKAAED AHLWRELVFL YAHYDEWDNA
     ALTMIEKSAD NFDHPYFKEV IVKVANLEIY YKAINFYVNE HPSLLVDLLS VLTPRLDIPR
     TVKIFSQSDN LPLIKPFLIN VLQKNNSVVN KAYHDLMIEE EDHQALQNAV DSYDKFDQLE
     LAGRLEKHDL IYFKKIAALL YRRNKKWSKA LDILKEQRLW KEAIETAAIS QDTKVVHDLL
     SYFVDTGNRE AFVALLYTAY NLIKYDFVLE VSWLNSLEDF IKPYEISVKK EQNAAVEKLS
     EEFAKKNNTS DDREGQPLML MNSSMHPQAT GF
//
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