ID NREC_STAAR Reviewed; 217 AA.
AC Q6GE42;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 01-MAY-2013, entry version 74.
DE RecName: Full=Oxygen regulatory protein NreC;
DE AltName: Full=Nitrogen regulation protein C;
GN Name=nreC; OrderedLocusNames=SAR2480;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T.,
RA Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L.,
RA Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K.,
RA James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K.,
RA Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M.,
RA Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G.,
RA Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains:
RT evidence for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Member of the two-component regulatory system NreB/NreC
CC involved in the control of dissimilatory nitrate/nitrite reduction
CC in response to oxygen. Phosphorylated NreC binds to a GC-rich
CC palindromic sequence at the promoters of the nitrate (narGHJI) and
CC nitrite (nir) reductase operons, as well as the putative nitrate
CC transporter gene narT, and activates their expression (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- PTM: Phosphorylated by NreB (By similarity).
CC -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; BX571856; CAG41461.1; -; Genomic_DNA.
DR RefSeq; YP_041831.1; NC_002952.2.
DR HSSP; P11470; 1FSE.
DR ProteinModelPortal; Q6GE42; -.
DR STRING; 282458.SAR2480; -.
DR EnsemblBacteria; CAG41461; CAG41461; SAR2480.
DR GeneID; 2859954; -.
DR KEGG; sar:SAR2480; -.
DR PATRIC; 19548652; VBIStaAur71814_2504.
DR eggNOG; COG2197; -.
DR HOGENOM; HOG000034813; -.
DR KO; K07696; -.
DR OMA; FKEADWI; -.
DR ProtClustDB; CLSK885949; -.
DR BioCyc; SAUR282458:GJA5-2524-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; Bipartite_resp_reg_C-effector; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 217 Oxygen regulatory protein NreC.
FT /FTId=PRO_0000349346.
FT DOMAIN 2 119 Response regulatory.
FT DOMAIN 148 213 HTH luxR-type.
FT DNA_BIND 172 191 H-T-H motif (By similarity).
FT MOD_RES 53 53 4-aspartylphosphate (By similarity).
SQ SEQUENCE 217 AA; 24354 MW; C029969C5F336324 CRC64;
MKIVIADDHA VVRTGFSMIL NYQNDMEVVA TAADGVEAYQ KVMEYKPDVL LMDLSMPPGE
SGLIATSKIA DSFPETKILI LTMFDDEEYL FHVLRNGAKG YILKNAPDEQ LLLAIRTVYK
GETYVDMKLT TSLVNEFVSN SNQDTANTSD PFKILSKREL EILPLIAKGY GNKEIAEKLF
VSVKTVEAHK THIMTKLGLK SKPELVEYAL KKKLLEF
//
