ID Q6GPM5_XENLA Unreviewed; 571 AA.
AC Q6GPM5;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Hbox10-A protein {ECO:0000313|EMBL:AAH73088.1};
DE SubName: Full=Homeobox-containing protein {ECO:0000313|RefSeq:NP_001081159.1};
GN Name=hbox10.S {ECO:0000313|RefSeq:NP_001081159.1,
GN ECO:0000313|Xenbase:XB-GENE-920327};
GN Synonyms=hbox10 {ECO:0000313|RefSeq:NP_001081159.1,
GN ECO:0000313|Xenbase:XB-GENE-920327}, hbox10-A
GN {ECO:0000313|EMBL:AAH73088.1, ECO:0000313|RefSeq:NP_001081159.1},
GN hbox10.L {ECO:0000313|RefSeq:NP_001081159.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH73088.1};
RN [1] {ECO:0000313|RefSeq:NP_001081159.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH73088.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocytes {ECO:0000313|EMBL:AAH73088.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001081159.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR EMBL; BC073088; AAH73088.1; -; mRNA.
DR RefSeq; NP_001081159.1; NM_001087690.1.
DR IntAct; Q6GPM5; 1.
DR DNASU; 394419; -.
DR GeneID; 394419; -.
DR KEGG; xla:394419; -.
DR AGR; Xenbase:XB-GENE-920327; -.
DR CTD; 394419; -.
DR Xenbase; XB-GENE-920327; hbox10.S.
DR OrthoDB; 4138438at2759; -.
DR Proteomes; UP000186698; Chromosome 7S.
DR Bgee; 394419; Expressed in oocyte and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR042988; NOBOX.
DR PANTHER; PTHR47060; HOMEOBOX PROTEIN NOBOX; 1.
DR PANTHER; PTHR47060:SF1; HOMEOBOX PROTEIN NOBOX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 177..237
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 179..238
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 61602 MW; 56EE9D6290988829 CRC64;
MDQEPEPDQQ QQVGEKPYQL GAQDEEETSL RCSEPEVEGQ HDEYGTVIIN EEAEGLGPSD
PGDFHLNSSE GCASEGGQCQ LSLLAVCGPL PETTGASYST FSGDDPQGPG YFPVRGQFQP
VNLKMESNFP SSAPLPRRSA RCAASCRLPT FIYDTGHGGD RQRGKCPGDA TEEPGPPCRK
KSRTLYSMDQ LQELEHMFAE DHYPDSEKRR EIAEIIGVTP QRIMVWFQNR RAKWRKVEKT
SLKGPRKPLS SAGMSHPETA VLTVSSSVAL SRPPEAVSLS VTSGFHSYGS SFPPVVGVRN
GLSVVPGSTL QTSQLSDGNS QHSTSLSSSS SGLGSPSEFC LPPSQEYPPT FPSPPPLRRV
GLPMSMAFNP SSHMVPLMLD TPESTCTPPP SCDGDMFSYA AQEYAIRSPT LQETMGSSMR
FGGQYYHPSN QPAAFQFPQY SQYSQYPRLP LHSLTPTSPE ETSFLTMPAN NPPGMLAYGG
TGAFLQGRTG GHILLPSGAG GITFHASPWS DMYLQNPSFQ RSQIGGNLTE QPLFSHPAPR
LAQPQKTSNP SQASEDQDST ATVSPDAAVT V
//
