ID Q6GQB1_XENLA Unreviewed; 1177 AA.
AC Q6GQB1;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=MGC80200 protein {ECO:0000313|EMBL:AAH72835.1};
DE SubName: Full=Neuronal cell adhesion molecule L homeolog precursor {ECO:0000313|RefSeq:NP_001085487.1};
GN Name=nrcam.L {ECO:0000313|RefSeq:NP_001085487.1,
GN ECO:0000313|Xenbase:XB-GENE-865900};
GN Synonyms=MGC80200 {ECO:0000313|EMBL:AAH72835.1}, nrcam
GN {ECO:0000313|RefSeq:NP_001085487.1,
GN ECO:0000313|Xenbase:XB-GENE-865900};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH72835.1};
RN [1] {ECO:0000313|RefSeq:NP_001085487.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH72835.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH72835.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001085487.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27942869;
RA Lokapally A., Metikala S., Hollemann T.;
RT "Xenopus laevis neuronal cell adhesion molecule (nrcam): plasticity of a
RT CAM in the developing nervous system.";
RL Dev. Genes Evol. 227:61-67(2017).
RN [4] {ECO:0000313|RefSeq:NP_001085487.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; BC072835; AAH72835.1; -; mRNA.
DR RefSeq; NP_001085487.1; NM_001092018.1.
DR GeneID; 443913; -.
DR KEGG; xla:443913; -.
DR AGR; Xenbase:XB-GENE-865900; -.
DR CTD; 443913; -.
DR Xenbase; XB-GENE-865900; nrcam.L.
DR OrthoDB; 2912783at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 443913; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05874; IgI_NrCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001085487.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1177
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001085487.1"
FT /id="PRO_5033206785"
FT TRANSMEM 1042..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 134..224
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 262..347
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 350..437
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 443..529
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 533..620
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 627..722
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 724..821
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 826..928
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 932..1028
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 707..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1177 AA; 130925 MW; 0C1C005089D4079F CRC64;
MQEKKSTFPK RASLVLFLCQ VITALEVPLD LLQPPTITHQ SPKNYIVDPR ESIVIQCEAK
GKPPPSFSWT RNGTHFDIDK DPYVTMKPNS GTLVINTMNG ARVDAYEGEY QCTARNDRGS
ALSNNIVIRQ SRSPLWTKEK IEPIVLQQGV PLVLPCNPPK GLPPPIIFWM DNSFQKLPQN
KRVSQGLNGD LYFSNVQPED TRDFYICYAR FNLTQTIHQK QPISLKVLTM DGLNETIAAN
LSDTEFYGDS PAGERRPSML FPNMTASNKT VLLGEVLLLE CIAEGLPTPE IHWRKESADL
PAGRVFYENF NKTLRIIDVT EADAGKYKCI GRNILGTTHH IITVNVKSSP YWISPPTNIV
LSPGEDGSLI CRASGNPTPS ITWLINGVSI ELAPTDASRR VDGDTIIFSK VQDGATAVYQ
CNVSNKYGYL LANAFVNVLA EPPRIMVLKH VYKVIANNVA LLHCPFFGSP KPEIKWFKGV
HGSILHGNGY VFHDNGTLEI PVAQKDSSGN YTCVATNTFG SVKDMIGLQI KDPTMIIKQP
EYRVIQRYGS AHFECRVKHD PTLKPVVLWL KDDSELLNDE RFKMTKGHLT IKNVTEKDEG
TYTCVANTDL DTVSASAVLT VVDRPNHPFD LELTDHHERS VQLSWVPGDD NNSPITNFMI
EYEDAMHDPG IWHFQAKVSG TQTTATLSLS PFVNYSFRVI AVNEIGSSDP SESSEQYMTK
PAEPDKNPSG IKGVGTEPDN LVIAWEPIKG FDSNGPGLQY KVSWRQKDFD DEWTSIIVAN
VSKYIVSGTP TFEPYEIKVQ ALNDIGYAPD PSVIIGYSGE DLPMTAPSNV EVEVINNTLA
KVQWESAPST SIRGHLQGYR VYYWKAENQT KRNKRHMEKH MLSFHGNKTH GMLPGLEPFK
SYIVNVRVFN GKGEGPPSTD KYFETPEGVP SAPLKLDIVE RTIDSLTLMW KPPAHPNGVL
TQYTLIFQSI NATHELSPPV EITIPTNETS LVLRNLNQST RYKFYLYANT AVGPGIQITQ
EAITALDQAM ASRQVDIATQ GWFIGLMCAV ALLILVLLII CFIRRNKGGK YPVKEKEDAH
ADPEIQPMKE DDGTFGEYSD AEDHKPLKKG SRTPSDRTVK KDDSDDSLVD YGEGVNGQFN
EDGSFIGQYS GKKEKEPVEG NESSEAPSPV NAMNSFV
//
