ID Q6INQ3_XENLA Unreviewed; 738 AA.
AC Q6INQ3;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=MGC81405 protein {ECO:0000313|EMBL:AAH72221.1};
DE SubName: Full=SH3 domain containing ring finger 2 S homeolog {ECO:0000313|RefSeq:NP_001085119.1};
GN Name=sh3rf2.S {ECO:0000313|RefSeq:NP_001085119.1,
GN ECO:0000313|Xenbase:XB-GENE-5763589};
GN Synonyms=hepp1 {ECO:0000313|RefSeq:NP_001085119.1}, MGC81405
GN {ECO:0000313|EMBL:AAH72221.1}, ppp1r39
GN {ECO:0000313|RefSeq:NP_001085119.1}, rnf158
GN {ECO:0000313|RefSeq:NP_001085119.1}, sh3rf2
GN {ECO:0000313|RefSeq:NP_001085119.1,
GN ECO:0000313|Xenbase:XB-GENE-5763589};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH72221.1};
RN [1] {ECO:0000313|RefSeq:NP_001085119.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH72221.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH72221.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001085119.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SH3RF family.
CC {ECO:0000256|ARBA:ARBA00008649}.
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DR EMBL; BC072221; AAH72221.1; -; mRNA.
DR RefSeq; NP_001085119.1; NM_001091650.1.
DR DNASU; 432194; -.
DR GeneID; 432194; -.
DR KEGG; xla:432194; -.
DR AGR; Xenbase:XB-GENE-5763589; -.
DR CTD; 432194; -.
DR Xenbase; XB-GENE-5763589; sh3rf2.S.
DR OrthoDB; 5407056at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 432194; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd16749; RING-HC_SH3RF2; 1.
DR CDD; cd11932; SH3_SH3RF2_2; 1.
DR CDD; cd11784; SH3_SH3RF2_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR028511; SH3RF2_RING-HC_Zfn.
DR InterPro; IPR035794; SH3RF2_SH3_2.
DR InterPro; IPR035822; SH3RF2_SH3_3.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR14167:SF60; E3 UBIQUITIN-PROTEIN LIGASE SH3RF2; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 12..53
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 184..248
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 377..438
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 600..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 81435 MW; B62C3B38F7CE0F54 CRC64;
MDDLVVLDLL DCPLCHGKLD VTAKVLPCQH TFCQPCLQRI FKARKELKCP ECRTPVQCSI
DELPANLLLV RILDGLKGGQ TLLRRNSSRR MGGLFIKDSL KKNKANRASQ DSTSRTISKA
GMPVDGQSFF KPLTANRCNS PRDLTLSKGD IIVLHRQLDE NWNNGQANRG SRISPETSGK
VLQPAPALCK AIYKFDLKEK NRESKDCLKF QKDDVISVIR RMDENWAEGK LGDQVGIFPL
MFVELNQTAK QLLESNKNNS HQNSTLPPLM KAPSKVKGTQ VTANHTMPEG RRKGPRQFLI
TNALNRFNKM VHSPTGRQTP EISSPILISS SNSAIIEKAE GLSTSPVQVN NSLYYPTFGT
QSNGTPLMAL PSSHQTILAN MCIVLHPYMA NGPEEMNLQK GEGVRVLGKF QEGWHRGVSL
VTGKIGLFPS YCVSPVYRKS PNYTDPRVSA NSTKWISSSA SVSSQGSMSE NGLSRPFRPF
VPTAVVEPMK QNMPSSSAAV TLRRNSKILR KCSTLQRNAQ SNSTALPMTS TYRPSSATIQ
SQPIHIFYNA SQSNVGTSAE NCLRPQSAYN AVSFGGRTND YRRYSTASYV FIETNESSAK
SDSMAKSPLR GPPSILVKPD TPKSTTDKVK TVRFLNFSPP PLKRQGSQIQ YSTRNEQLIT
EAPKAEGTAA SETISNQQPR ANPMLIKPTD NRGMYKLRSS SSDIVVPKSP ISVASKRAPN
DSMKRWSAVY YPQDILSS
//
