ID Q6IRQ3_XENLA Unreviewed; 377 AA.
AC Q6IRQ3;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 99.
DE SubName: Full=MGC82221 protein {ECO:0000313|EMBL:AAH70654.1};
DE SubName: Full=Uncharacterized protein LOC432021 {ECO:0000313|RefSeq:NP_001084962.1};
GN Name=MGC82221 {ECO:0000313|EMBL:AAH70654.1,
GN ECO:0000313|RefSeq:NP_001084962.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH70654.1};
RN [1] {ECO:0000313|RefSeq:NP_001084962.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH70654.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAH70654.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001084962.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC070654; AAH70654.1; -; mRNA.
DR RefSeq; NP_001084962.1; NM_001091493.1.
DR GeneID; 432021; -.
DR KEGG; xla:432021; -.
DR OrthoDB; 1077476at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 432021; Expressed in zone of skin and 16 other cell types or tissues.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08299; alcohol_DH_class_I_II_IV; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF1; ALCOHOL DEHYDROGENASE 1A; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 2: Evidence at transcript level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 35..124
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 204..337
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 377 AA; 40203 MW; A7FDD4A36B1B9017 CRC64;
MTTAGNVIKC KAAVAWAPKQ PLSIEDIEVA PPKAHEIRVK MVATGICGSD DTVLSGSFSS
IKFPVILGHE GAGIVESVGT GVKNVKPGDK VIALFQPQCG ECQNCLNPKS NMCFKSDLGK
YTGMMLDNTS RFTCKGKLIH HFMHTSTFTE YTVLDEIAVA KIQDDAPLDK VCLISCGFSA
GYGSVLNTAQ VKQGSTCAVF GLGGVGLSVV IGCRVAGAAK IIGVDTNSDK FPKAKEIGAT
ECVNPNDYKE PIHKVLEKMT EGGLDYSFEC VGNTSVMASA LLSTNYSYGT SVIVGVAPLA
AELNLNPMEI LTGRTLKGTL FGGWKGRDCV PKLVADFMAK KFELDGLITH RLPLQNINEG
FDLLHKGESL RTVLYFC
//