ID Q6JD67_TOXGO Unreviewed; 347 AA.
AC Q6JD67;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Eukaryotic initiation factor-2 alpha subunit {ECO:0000313|EMBL:AAS48462.1};
OS Toxoplasma gondii.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=5811 {ECO:0000313|EMBL:AAS48462.1};
RN [1] {ECO:0000313|EMBL:AAS48462.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14989696;
RA Sullivan W.J.Jr., Narasimhan J., Bhatti M.M., Wek R.C.;
RT "Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required
RT for stress-induced translation control.";
RL Biochem. J. 380:523-531(2004).
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family.
CC {ECO:0000256|ARBA:ARBA00007223}.
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DR EMBL; AY518935; AAS48462.1; -; mRNA.
DR AlphaFoldDB; Q6JD67; -.
DR VEuPathDB; ToxoDB:TGARI_313230A; -.
DR VEuPathDB; ToxoDB:TGCAST_313230; -.
DR VEuPathDB; ToxoDB:TGCOUG_313230A; -.
DR VEuPathDB; ToxoDB:TGDOM2_313230; -.
DR VEuPathDB; ToxoDB:TGFOU_313230A; -.
DR VEuPathDB; ToxoDB:TGGT1_313230; -.
DR VEuPathDB; ToxoDB:TGMAS_313230A; -.
DR VEuPathDB; ToxoDB:TGME49_313230; -.
DR VEuPathDB; ToxoDB:TGP89_313230; -.
DR VEuPathDB; ToxoDB:TGPRC2_313230; -.
DR VEuPathDB; ToxoDB:TGRH88_052360; -.
DR VEuPathDB; ToxoDB:TGRUB_313230; -.
DR VEuPathDB; ToxoDB:TGVAND_313230; -.
DR VEuPathDB; ToxoDB:TGVEG_313230; -.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 3.30.70.1130; EIF_2_alpha; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR PANTHER; PTHR10602:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; eIF-2-alpha, C-terminal domain; 1.
DR SUPFAM; SSF116742; eIF2alpha middle domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 2: Evidence at transcript level;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:AAS48462.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 36..107
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 302..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 39156 MW; 6BBE2B48B064DC69 CRC64;
MEARDGMSSQ GATGAAVPKA DLGDCRFYEE RFPDVEDLVM VKVNRIADLG AYVSLLEYNN
MEGMILMSEL SKRRFRSVNK LIRVGRHEVV MVLRVDPKKG YIDLSKRRVS PEDIVKCEEK
FSKSKKVHQT VRHAAQKHGM KVDDLNRSVI WPLYRKYGHA LDALKEAAMR PDEVFAGLEV
DEEVRKSLIQ DIQLRLAPQA LKLRARVDVW CFGKQGIDAV KAALQAGQEV GDDEVTINIK
LIAPPQYVVV TSCYDKELGM RKIEQAMKAI SDKIKSFSGG DFKQQGEIVV MGGDEEKRLE
ELLEEANEDD SSDDEEEEED EGMGRVEDDI PEDEVEDDEE DNDDGNA
//
