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Database: UniProt
Entry: Q6KZG0
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Original site: Q6KZG0 
ID   COXX2_PICTO             Reviewed;         289 AA.
AC   Q6KZG0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   26-NOV-2014, entry version 68.
DE   RecName: Full=Protoheme IX farnesyltransferase 2 {ECO:0000255|HAMAP-Rule:MF_00154};
DE            EC=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme B farnesyltransferase 2 {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme O synthase 2 {ECO:0000255|HAMAP-Rule:MF_00154};
GN   Name=ctaB2 {ECO:0000255|HAMAP-Rule:MF_00154};
GN   OrderedLocusNames=PTO1307;
OS   Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC
OS   100828).
OC   Archaea; Euryarchaeota; Thermoplasmata; Thermoplasmatales;
OC   Picrophilaceae; Picrophilus.
OX   NCBI_TaxID=263820;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828;
RX   PubMed=15184674; DOI=10.1073/pnas.0401356101;
RA   Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C.,
RA   Schepers B., Dock C., Antranikian G., Liebl W.;
RT   "Genome sequence of Picrophilus torridus and its implications for life
RT   around pH 0.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004).
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00154}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
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DR   EMBL; AE017261; AAT43892.1; -; Genomic_DNA.
DR   RefSeq; WP_011178108.1; NC_005877.1.
DR   RefSeq; YP_024085.1; NC_005877.1.
DR   ProteinModelPortal; Q6KZG0; -.
DR   STRING; 263820.PTO1307; -.
DR   EnsemblBacteria; AAT43892; AAT43892; PTO1307.
DR   GeneID; 2844344; -.
DR   KEGG; pto:PTO1307; -.
DR   eggNOG; COG0109; -.
DR   HOGENOM; HOG000237291; -.
DR   KO; K02301; -.
DR   OMA; ILNANTR; -.
DR   BioCyc; PTOR263820:GHA3-1355-MONOMER; -.
DR   UniPathway; UPA00834; UER00712.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Heme biosynthesis; Membrane;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN         1    289       Protoheme IX farnesyltransferase 2.
FT                                /FTId=PRO_0000327197.
FT   TRANSMEM     13     33       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     37     57       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     86    106       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    109    129       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    137    157       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    159    179       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    207    227       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    232    252       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    267    287       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
SQ   SEQUENCE   289 AA;  32307 MW;  C87A610986203CE1 CRC64;
     MSMTSQIMKI TKLEITILID IVAIAAFLAV PGSTNHIYDL LILIFAGTLA SMSASIFNNI
     YDMDIDPKMK RTSSRSQILN ANTRSLFFII ATAMVLLSFV TSFILLNPVT SAFILGGFAS
     YVLLYTIILK RRTSLNIVIG GIAGSFPALA GWASITGSVS ATSLFIAFLV FMWTPTHFWN
     LSVNNVDDYK KSNIPMLPAV VGIKRTEFWI MVNTSILVIY SILPLFIKEI HVGLLYMPMA
     AVMDALLIYY VARPMINNYN KKDFKKAFHF SNMYMLMLLI GIMLILVKF
//
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