ID COXX2_PICTO Reviewed; 289 AA.
AC Q6KZG0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 29-MAY-2013, entry version 62.
DE RecName: Full=Protoheme IX farnesyltransferase 2;
DE EC=2.5.1.-;
DE AltName: Full=Heme B farnesyltransferase 2;
DE AltName: Full=Heme O synthase 2;
GN Name=ctaB2; OrderedLocusNames=PTO1307;
OS Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC
OS 100828).
OC Archaea; Euryarchaeota; Thermoplasmata; Thermoplasmatales;
OC Picrophilaceae; Picrophilus.
OX NCBI_TaxID=263820;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828;
RX PubMed=15184674; DOI=10.1073/pnas.0401356101;
RA Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C.,
RA Schepers B., Dock C., Antranikian G., Liebl W.;
RT "Genome sequence of Picrophilus torridus and its implications for life
RT around pH 0.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004).
CC -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC hydroxyethyl farnesyl side group (By similarity).
CC -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC biosynthesis; heme O from protoheme: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (Potential).
CC -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC according to the Fischer nomenclature (By similarity).
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC Protoheme IX farnesyltransferase subfamily.
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DR EMBL; AE017261; AAT43892.1; -; Genomic_DNA.
DR RefSeq; YP_024085.1; NC_005877.1.
DR ProteinModelPortal; Q6KZG0; -.
DR STRING; 263820.PTO1307; -.
DR EnsemblBacteria; AAT43892; AAT43892; PTO1307.
DR GeneID; 2844344; -.
DR KEGG; pto:PTO1307; -.
DR eggNOG; COG0109; -.
DR HOGENOM; HOG000237291; -.
DR KO; K02301; -.
DR BioCyc; PTOR263820:GHA3-1355-MONOMER; -.
DR UniPathway; UPA00834; UER00712.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:HAMAP.
DR GO; GO:0048034; P:heme O biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00154; CyoE_CtaB; 1; -.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR PROSITE; PS00943; UBIA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Heme biosynthesis; Membrane;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1 289 Protoheme IX farnesyltransferase 2.
FT /FTId=PRO_0000327197.
FT TRANSMEM 13 33 Helical; (Potential).
FT TRANSMEM 37 57 Helical; (Potential).
FT TRANSMEM 86 106 Helical; (Potential).
FT TRANSMEM 109 129 Helical; (Potential).
FT TRANSMEM 137 157 Helical; (Potential).
FT TRANSMEM 159 179 Helical; (Potential).
FT TRANSMEM 207 227 Helical; (Potential).
FT TRANSMEM 232 252 Helical; (Potential).
FT TRANSMEM 267 287 Helical; (Potential).
SQ SEQUENCE 289 AA; 32307 MW; C87A610986203CE1 CRC64;
MSMTSQIMKI TKLEITILID IVAIAAFLAV PGSTNHIYDL LILIFAGTLA SMSASIFNNI
YDMDIDPKMK RTSSRSQILN ANTRSLFFII ATAMVLLSFV TSFILLNPVT SAFILGGFAS
YVLLYTIILK RRTSLNIVIG GIAGSFPALA GWASITGSVS ATSLFIAFLV FMWTPTHFWN
LSVNNVDDYK KSNIPMLPAV VGIKRTEFWI MVNTSILVIY SILPLFIKEI HVGLLYMPMA
AVMDALLIYY VARPMINNYN KKDFKKAFHF SNMYMLMLLI GIMLILVKF
//
