ID Q6LBS1_HUMAN Unreviewed; 218 AA.
AC Q6LBS1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=SmB /B' autoimmune antigene {ECO:0000313|EMBL:CAA34288.1};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAA34288.1};
RN [1] {ECO:0000313|EMBL:CAA34288.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2753153; DOI=10.1016/0014-5793(89)80801-4;
RA Sharpe N.G., Williams D.G., Howarth D.N., Coles B., Latchman D.S.;
RT "Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen
RT and specifically reacting with human anti-Sm auto-immune sera.";
RL FEBS Lett. 250:585-590(1989).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the snRNP SmB/SmN family.
CC {ECO:0000256|ARBA:ARBA00009123}.
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DR EMBL; X16163; CAA34288.1; -; mRNA.
DR AlphaFoldDB; Q6LBS1; -.
DR PeptideAtlas; Q6LBS1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd01717; Sm_B; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR047575; Sm.
DR InterPro; IPR001163; Sm_dom_euk/arc.
DR InterPro; IPR017131; snRNP-assoc_SmB/SmN.
DR PANTHER; PTHR10701:SF0; SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B; 1.
DR PANTHER; PTHR10701; SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N; 1.
DR Pfam; PF01423; LSM; 1.
DR PIRSF; PIRSF037187; snRNP_SmB/SmN; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS52002; SM; 1.
PE 2: Evidence at transcript level;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274}.
FT DOMAIN 1..64
FT /note="Sm"
FT /evidence="ECO:0000259|PROSITE:PS52002"
FT REGION 141..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..218
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAA34288.1"
SQ SEQUENCE 218 AA; 21993 MW; 44E23A7481B58FAF CRC64;
DGRIFIGTFK AFDKHMNLIL CDCDEFRKIK PKNAKQPERE EKRVLGLVLL RGENLVSMTV
EGPPPKDTGI ARVPLAGAAG GPGVGRAAGR GVPAGVPIPQ APAGLAGPVR GVGGPSQQVM
TPQGRGTVAA AAVAATASIA GAPTQYPPGR GTPPPPVGRA TPPPGIMAPP PGMRPPMGPP
IGLPPARGTP IGMPPPGMRP PPPGIRGPPP PGMRPPRP
//
