ID Q6LYW5_METMP Unreviewed; 318 AA.
AC Q6LYW5;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=2-hydroxyacid dehydrogenase, D-isomer specific {ECO:0000313|EMBL:CAF30426.1};
DE EC=1.1.1.29 {ECO:0000313|EMBL:CAF30426.1};
GN OrderedLocusNames=MMP0870 {ECO:0000313|EMBL:CAF30426.1};
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377 {ECO:0000313|Proteomes:UP000000590};
RN [1] {ECO:0000313|EMBL:CAF30426.1, ECO:0000313|Proteomes:UP000000590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL {ECO:0000313|Proteomes:UP000000590};
RX PubMed=15466049; DOI=10.1128/JB.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soll D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; BX950229; CAF30426.1; -; Genomic_DNA.
DR RefSeq; WP_011170814.1; NC_005791.1.
DR AlphaFoldDB; Q6LYW5; -.
DR STRING; 267377.MMP0870; -.
DR EnsemblBacteria; CAF30426; CAF30426; MMP0870.
DR GeneID; 2761714; -.
DR KEGG; mmp:MMP0870; -.
DR PATRIC; fig|267377.15.peg.896; -.
DR eggNOG; arCOG01755; Archaea.
DR HOGENOM; CLU_019796_1_3_2; -.
DR OrthoDB; 34275at2157; -.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0008465; F:glycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12162; 2-Hacid_dh_4; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000000590}.
FT DOMAIN 19..317
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 108..286
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 318 AA; 34993 MW; 4F48996B3109637F CRC64;
MKIVVLDGYA MNSGDLSWED LKKLGELSIY DRTLESEVVE RISDSEIVIT NKVIIGKEVL
EKCKNIKYVG VTATGYNVVD TTLAKDHGVI VTNVPAYSTD SVAQLVFSFI LEHCQNVSKY
TESVKSGDWV NSKDFSYQKF PIIELAGKSL GIIGFGAIGK KVAEIGNAFG MNVLVNTRTV
SKTDEINVNF VSKEEIFKNS DFLTLHCPLN NETDKIVNEK TLNLMKKSAI LINTGRGGLV
NEKDLANALN LEKIAGAGLD VLSTEPPKED NPLLNAKNTY ITPHVAWASY EARKRLMDVT
INNVKSFIDG NPINVVNK
//
