ID Q6MFS6_NEUCS Unreviewed; 1157 AA.
AC Q6MFS6;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Related to DNA mismatch repair protein PMS1 {ECO:0000313|EMBL:CAE85513.1};
GN ORFNames=B2N18.120 {ECO:0000313|EMBL:CAE85513.1}, GE21DRAFT_6247
GN {ECO:0000313|EMBL:KHE84414.1};
OS Neurospora crassa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=5141 {ECO:0000313|EMBL:CAE85513.1};
RN [1] {ECO:0000313|EMBL:CAE85513.1}
RP NUCLEOTIDE SEQUENCE.
RA German Neurospora genome project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAE85513.1}
RP NUCLEOTIDE SEQUENCE.
RA Schulte U., Aign V., Hoheisel J., Brandt P., Fartmann B., Holland R.,
RA Nyakatura G., Mewes H.W., Mannhaupt G.;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KHE84414.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=73 {ECO:0000313|EMBL:KHE84414.1};
RG DOE Joint Genome Institute;
RA Baker S.E., Grigoriev I., Haridas S., LaButti K., McCluskey K.;
RT "Draft genome sequence of Neurospora crassa strain FGSC 73.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; BX897674; CAE85513.1; -; Genomic_DNA.
DR EMBL; KN389673; KHE84414.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:NCU08020; -.
DR eggNOG; KOG1978; Eukaryota.
DR HOGENOM; CLU_004131_0_0_1; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000053122; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763}.
FT DOMAIN 220..360
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 888..1062
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 376..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..685
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1157
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 127633 MW; AECCC4FEF9ECEE76 CRC64;
MASDGAIKAI DPSTIHQIQS GQVIVDLCSV AKELVENALD AGATTIDVRF KNQGLDSIEV
QDNGSGISSS NYESIALKHY TSKLSNYDDL STLQTFGFRG EALSSLCALS HFTIVTCTQK
EAPKATKLEF ETSGKLKSTS VVSGQRGTTV SVENLFKSLP VRRRELERNI KREWGKVVNL
LNQYACIQTS VKFTVSQQPT KGKRMVLFST KGNPTTRENI INVFGIKTMT ALIAMDLRLQ
LKPTNTGLLA KMTAQDDDAM TEVRICGHIS RPAHGEGRQT PDRQMFYVNG RPCGLPQFAK
VFNEVYRSYN STQSPFIFAD IQLDTHLYDV NVSPDKRTIL LHDQGQMLDN LRESLIELFE
LQDVTIPVSH TQLLKGSTFR GPSTVPLGSL TPAREKDSRD ASEEPGSSLP SNRPENGPQG
NRATRHAVNE DSDEAVSDED NAPNTLSTGP KTRAGPCEST PANTQASNLL ARWLERKSEA
RKQPVSAAIN ANDSRREKSP VEKEPQSPKR ARRYDTKDAE SDAEQDTAED NEHVENNSMT
QDVVDDKEMD RQELTMPSIP PPTQPPIPKG SLLSISRPPK RSAQEEVATI TIGGHSITSV
IGSSNKRSRL SEGMRSVSLG SSPTKGIRTV PVPSFGGRLT QLFSASGGAS RGVSKDLEMT
TEDVEMVDEE GKGEENEEGN ETEKGVDSDD EALFVSQTKD VPAVEYDDVD EQAEHSTREN
SPADEEGNGP ISGQTNQSVA EGDDNGEVEL SEDAPSECCH HGDDDEEYID EDEKKAKEEK
KVQEMIKAAE KKANEPTEEG EKRSQSFVKG RLKRKDLTFN LIQRLKTSEG DIRSRMEIWA
KHLPRAGTAS SSTQESSDGK PTIGLDAADA EEKLSLKISK SDFAKMKIVG QFNLGFIIAV
REASSSHSLE HSPSQQSPAA TTQEDDELFI IDQHASDEKY NFERLQSTTT VQSQRLVQPK
PLTLTAVEEE IILEHLPALA ANGFQVRVDT SGESAVGSRC QLLSLPLSRE TTFGVADLEE
LIFLLGDNPT SSATTAIPRP SKVRKMFAMR ACRSSIMIGR ALSRPQMEKV VRHMGEMEKP
WNCPHGRPTM RHLCGLGSAF GEGIKEKERG WDEWEGVERE RVDWKAWVRE KREDAEEGEG
EGQEEEEEEE EEEEMSE
//
