ID Q6MLN6_BDEBA Unreviewed; 400 AA.
AC Q6MLN6;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Signal transduction protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=Bd1971 {ECO:0000313|EMBL:CAE79821.1};
OS Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 /
OS HD100).
OC Bacteria; Bdellovibrionota; Bdellovibrionia; Bdellovibrionales;
OC Pseudobdellovibrionaceae; Bdellovibrio.
OX NCBI_TaxID=264462 {ECO:0000313|EMBL:CAE79821.1, ECO:0000313|Proteomes:UP000008080};
RN [1] {ECO:0000313|EMBL:CAE79821.1, ECO:0000313|Proteomes:UP000008080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100
RC {ECO:0000313|Proteomes:UP000008080};
RX PubMed=14752164; DOI=10.1126/science.1093027;
RA Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C.,
RA Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E.,
RA Schuster S.C.;
RT "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a
RT genomic perspective.";
RL Science 303:689-692(2004).
RN [2] {ECO:0007829|PDB:6HQ2, ECO:0007829|PDB:6HQ3}
RP X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 4-111 IN COMPLEX WITH
RP 3',5'-CYCLIC AMP; 3',5'-CYCLIC GMP; CA(2+); MG(2+) AND CYCLIC
RP DI-3',5'-GUANYLATE.
RX PubMed=31355487; DOI=10.15252/embj.2018100772;
RA Cadby I.T., Basford S.M., Nottingham R., Meek R., Lowry R., Lambert C.,
RA Tridgett M., Till R., Ahmad R., Fung R., Hobley L., Hughes W.S.,
RA Moynihan P.J., Sockett R.E., Lovering A.L.;
RT "Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-
RT GMP phosphodiesterase.";
RL EMBO J. 38:e100772-e100772(2019).
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DR EMBL; BX842651; CAE79821.1; -; Genomic_DNA.
DR RefSeq; WP_011164423.1; NC_005363.1.
DR PDB; 6HQ2; X-ray; 2.45 A; A/B=4-111.
DR PDB; 6HQ3; X-ray; 2.79 A; A/B/C/D=4-114.
DR PDB; 6HQ4; X-ray; 2.63 A; A/B=6-400.
DR PDB; 6HQ5; X-ray; 2.83 A; A/B=5-400.
DR PDB; 6HQ7; X-ray; 2.46 A; A/B=6-400.
DR PDBsum; 6HQ2; -.
DR PDBsum; 6HQ3; -.
DR PDBsum; 6HQ4; -.
DR PDBsum; 6HQ5; -.
DR PDBsum; 6HQ7; -.
DR AlphaFoldDB; Q6MLN6; -.
DR SMR; Q6MLN6; -.
DR STRING; 264462.Bd1971; -.
DR KEGG; bba:Bd1971; -.
DR eggNOG; COG0664; Bacteria.
DR eggNOG; COG2200; Bacteria.
DR HOGENOM; CLU_000445_144_1_7; -.
DR Proteomes; UP000008080; Chromosome.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd01948; EAL; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00563; EAL; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00052; EAL; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50883; EAL; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6HQ2, ECO:0007829|PDB:6HQ3};
KW Calcium {ECO:0007829|PDB:6HQ5};
KW Metal-binding {ECO:0007829|PDB:6HQ4, ECO:0007829|PDB:6HQ5};
KW Nucleotide-binding {ECO:0007829|PDB:6HQ3, ECO:0007829|PDB:6HQ4};
KW Reference proteome {ECO:0000313|Proteomes:UP000008080}.
FT DOMAIN 1..108
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 143..400
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT BINDING 57
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ3, ECO:0007829|PDB:6HQ4"
FT BINDING 57
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 57
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0007829|PDB:6HQ7"
FT BINDING 58
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ3, ECO:0007829|PDB:6HQ4"
FT BINDING 58
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 58
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0007829|PDB:6HQ7"
FT BINDING 59
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 59
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ3, ECO:0007829|PDB:6HQ4"
FT BINDING 59
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0007829|PDB:6HQ7"
FT BINDING 60
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 60
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ3, ECO:0007829|PDB:6HQ4"
FT BINDING 60
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0007829|PDB:6HQ7"
FT BINDING 67
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 67
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ3, ECO:0007829|PDB:6HQ4"
FT BINDING 67
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0007829|PDB:6HQ7"
FT BINDING 68
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ3, ECO:0007829|PDB:6HQ4"
FT BINDING 68
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 68
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0007829|PDB:6HQ7"
FT BINDING 108
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ3, ECO:0007829|PDB:6HQ4"
FT BINDING 108
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0007829|PDB:6HQ7"
FT BINDING 111
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ3"
FT BINDING 111
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0007829|PDB:6HQ7"
FT BINDING 112
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 113
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 113
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ4, ECO:0007829|PDB:6HQ5"
FT BINDING 164
FT /ligand="3',3'-c-di-GMP"
FT /ligand_id="ChEBI:CHEBI:58805"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 178
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 178
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0007829|PDB:6HQ4, ECO:0007829|PDB:6HQ7"
FT BINDING 181
FT /ligand="3',3'-c-di-GMP"
FT /ligand_id="ChEBI:CHEBI:58805"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 182
FT /ligand="3',3'-c-di-GMP"
FT /ligand_id="ChEBI:CHEBI:58805"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 201
FT /ligand="3',3'-c-di-GMP"
FT /ligand_id="ChEBI:CHEBI:58805"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 245
FT /ligand="3',3'-c-di-GMP"
FT /ligand_id="ChEBI:CHEBI:58805"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 245
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 245
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0007829|PDB:6HQ4"
FT BINDING 277
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 277
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0007829|PDB:6HQ4, ECO:0007829|PDB:6HQ7"
FT BINDING 306
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 306
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 306
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0007829|PDB:6HQ4, ECO:0007829|PDB:6HQ7"
FT BINDING 307
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 329
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 330
FT /ligand="3',3'-c-di-GMP"
FT /ligand_id="ChEBI:CHEBI:58805"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 363
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 366
FT /ligand="3',3'-c-di-GMP"
FT /ligand_id="ChEBI:CHEBI:58805"
FT /evidence="ECO:0007829|PDB:6HQ5"
FT BINDING 385
FT /ligand="3',3'-c-di-GMP"
FT /ligand_id="ChEBI:CHEBI:58805"
FT /evidence="ECO:0007829|PDB:6HQ5"
SQ SEQUENCE 400 AA; 44971 MW; 5FCB1F6D900C2B93 CRC64;
MNAAAQSVDI HKDQIIFSEG DAGDCAYIIE KGRVLIYLTK DKEEIPLTIL GEGEIFGEMA
LIDNQNRSAS VRALEDVRLA IVTKQQVLER VSTADKVVQL LMRVLLKRLR RKNIGGPGGS
RISEVEFDNS GAGDDGTQSA LDQIKLENQI FQAFQNKEFE LFYQPIVNLK NKTITGCEAL
LRWNSPQHGL VSPNLFIDII ENSSMVIPIG HWIINQALKD LRTIQDQLRL NKKERMADDF
MMSINISGRQ FTHSDFVNNL EDLREKHDLH TQNIKLEMTE RIMMDGAIAI DALNQCRSLG
YAISIDDFGT GFSGLQYLTQ MPISFLKIDR SFVMKILSDP KSKAVVSSII HLAHAMDIEV
IAEGIEHHEE ALVLETLGAR FGQGYLFSKP VDLGRFLKLI
//
