ID GLPK_MYCMS Reviewed; 505 AA.
AC Q6MTY7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 01-MAY-2013, entry version 66.
DE RecName: Full=Glycerol kinase;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase;
DE AltName: Full=Glycerokinase;
DE Short=GK;
GN Name=glpK; OrderedLocusNames=MSC_0258;
OS Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG1;
RX PubMed=14762060; DOI=10.1101/gr.1673304;
RA Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA Johansson K.-E., Pettersson B., Uhlen M.;
RT "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type
RT strain PG1T, the causative agent of contagious bovine pleuropneumonia
RT (CBPP).";
RL Genome Res. 14:221-227(2004).
CC -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC metabolism (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC phosphate.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR EMBL; BX293980; CAE76899.1; -; Genomic_DNA.
DR RefSeq; NP_975257.1; NC_005364.2.
DR HSSP; P0A6F3; 1GLC.
DR ProteinModelPortal; Q6MTY7; -.
DR SMR; Q6MTY7; 4-503.
DR STRING; 272632.MSC_0258; -.
DR EnsemblBacteria; CAE76899; CAE76899; MSC_0258.
DR GeneID; 2744286; -.
DR KEGG; mmy:MSC_0258; -.
DR PATRIC; 20017246; VBIMycMyc4973_0279.
DR eggNOG; COG0554; -.
DR HOGENOM; HOG000222134; -.
DR KO; K00864; -.
DR OMA; TEANIDT; -.
DR ProtClustDB; CLSK829635; -.
DR BioCyc; MMYC272632:GI1G-247-MONOMER; -.
DR UniPathway; UPA00618; UER00672.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR HAMAP; MF_00186; Glycerol_kin; 1; -.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR PANTHER; PTHR10196:SF9; PTHR10196:SF9; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1 505 Glycerol kinase.
FT /FTId=PRO_1000020747.
FT NP_BIND 415 419 ATP (By similarity).
FT BINDING 15 15 Substrate (By similarity).
FT BINDING 19 19 ATP (By similarity).
FT BINDING 85 85 Substrate (By similarity).
FT BINDING 136 136 Substrate (By similarity).
FT BINDING 249 249 Substrate (By similarity).
FT BINDING 271 271 ATP (By similarity).
FT BINDING 314 314 ATP; via carbonyl oxygen (By similarity).
SQ SEQUENCE 505 AA; 57332 MW; 7A3A2667B51F2FD9 CRC64;
MTDSKKYILT LDEGTTSARA LITDKQGNII AVEQSEFTQY FPKEGWVEHD AIEIWNTQRS
ALVQVLNKSG IDPSQIEAIG ITNQRETAVI WNKETGLPIY NAIVWQDQRT ADYCQTFDKD
TLEMVKQRSG LIINPYFSGT KVKWILDNVP NARQLAKEGK LMFGTINTWL IYRLTGGEVF
VTDHTNAQRT LLYNIHTNDW DDELLKLFDI PRNILPEIKS CSEVYGYTFK GLFSKGNEQR
IKIASSIGDQ QSALFGQLCL EKGQVKVTYG TGCFILTNTG EEIVKSNHGL LTTVAYSFKD
KVYYALEGSV MIAGAAVQWL RDNLRIVYNA IETEWYADQV KDDRRVYVVP SFTGLGSPYW
DSFSRGAIFG LDRGTRREHI VRATLEAIVY QANDVVDAMR KDMKKPIEIF KVDGGAANNK
FLMQFQSNIS QSKVIKPTNV ETTAMGAAFM VGLAVGYWEN AEELKKTYKV HFELTPELSK
PEVDKLIKGW KVAVQRTFKW VEEIE
//
