ID Q6MU83_MYCMS Unreviewed; 509 AA.
AC Q6MU83;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 112.
DE SubName: Full=Cardiolipin synthetase {ECO:0000313|EMBL:CAE76801.1};
DE EC=2.7.8.- {ECO:0000313|EMBL:CAE76801.1};
GN Name=cls {ECO:0000313|EMBL:CAE76801.1};
GN OrderedLocusNames=MSC_0156 {ECO:0000313|EMBL:CAE76801.1};
OS Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272632 {ECO:0000313|EMBL:CAE76801.1, ECO:0000313|Proteomes:UP000001016};
RN [1] {ECO:0000313|EMBL:CAE76801.1, ECO:0000313|Proteomes:UP000001016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG1 {ECO:0000313|EMBL:CAE76801.1,
RC ECO:0000313|Proteomes:UP000001016};
RX PubMed=14762060; DOI=10.1101/gr.1673304;
RA Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA Johansson K.-E., Pettersson B., Uhlen M.;
RT "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain
RT PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
RL Genome Res. 14:221-227(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX293980; CAE76801.1; -; Genomic_DNA.
DR RefSeq; NP_975159.1; NC_005364.2.
DR AlphaFoldDB; Q6MU83; -.
DR STRING; 272632.MSC_0156; -.
DR KEGG; mmy:MSC_0156; -.
DR PATRIC; fig|272632.4.peg.165; -.
DR eggNOG; COG1502; Bacteria.
DR HOGENOM; CLU_038053_1_2_14; -.
DR OMA; TRFILDW; -.
DR Proteomes; UP000001016; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR CDD; cd09110; PLDc_CLS_1; 1.
DR CDD; cd09112; PLDc_CLS_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR022924; Cardiolipin_synthase.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000001016};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAE76801.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 240..267
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 422..449
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 509 AA; 59855 MW; D5EF7B4BE716CE1F CRC64;
MKKPIVTVLS LVFMFGLTIF GLLLLNIYFF TWPLIGFGIF HLLAIIWAFI VLADKKRRFE
TRIRWFCFIV CIPIIGVLSY LFFGRSYKYK ITKNYKFLEI KNKHLENELE QIDQILTNQI
PQFKRAFKTA SISQTSNIFL NTKVEFLENG NQLFLNLFKD IKNAKHYILL NFYIFKDGKL
LDELTNLLIR KLKENVKVYI IYDFAGSYTL FEEAKIKLLE YGCQIVCYAP IRFPFIKWTA
NYRDHRKDIV IDNKIGYIGG INIGDEYINL DNKFGYWNDC SLKITGNAVS EIQRIFISDF
DFYKPSFKKI SIKQDLDLNN IYPVKCKDQL VQIVSSGPNH EEPLHLSIFI NLINSAQKRI
WISTPYFIPP QEIRTALINA ANSKLDVRIL IPGLTDKAFL LDQTKQWTRE LYKAGVKIYS
INNVFNHNKT YLFDDEITFI GSTNLDFRAL FADQQTMGLI YSKSLNKTIS NKFEQDFKNS
YLYDHLPNKN INWFRKIVIK IYNIIQPLL
//