ID   Q6MXV5_SERMA            Unreviewed;       679 AA.
AC   Q6MXV5;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   ORFNames=SMR0088 {ECO:0000313|EMBL:CAE51614.1};
OS   Serratia marcescens.
OG   Plasmid R478 {ECO:0000313|EMBL:CAE51614.1}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615 {ECO:0000313|EMBL:CAE51614.1};
RN   [1] {ECO:0000313|EMBL:CAE51614.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   PLASMID=R478 {ECO:0000313|EMBL:CAE51614.1};
RX   PubMed=15518875; DOI=10.1016/j.plasmid.2004.06.006;
RA   Gilmour M.W., Thomson N.R., Saunders M., Parkhill J., Taylor D.E.;
RT   "The complete nucleotide sequence of the resistance plasmid R478: defining
RT   the backbone components of incompatibility group H conjugative plasmids
RT   through comparative genomics.";
RL   Plasmid 52:182-202(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX664015; CAE51614.1; -; Genomic_DNA.
DR   RefSeq; NP_941161.1; NC_005211.1.
DR   RefSeq; WP_000166877.1; NZ_VOMJ01000014.1.
DR   AlphaFoldDB; Q6MXV5; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Plasmid {ECO:0000313|EMBL:CAE51614.1}.
FT   BINDING         24..31
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   679 AA;  76528 MW;  366F46CA5E933BE6 CRC64;
     MTKRLTWEQK SIVSHDTGHA LVKAVPGSGK TTTLVKRVER LVKTGTDPRS ILILMYNKSA
     QVSFTENLKT ALMSSVIPEI RTFHSLALKI VGYGERQQII KKKDLITPSD YRYEQLVKQA
     YRYGFDHEAN YIDPNEIENF ELFIARCRAA AVTPVDAAND PTFSNIKREF IHAYGRYCEL
     LEENSLRTFD DCLIEAVALL RNDSSLGAHF KHIIVDEYQD VNLIQHDMTR LLSKSDTSVM
     AVGDVNQCIY EWRGARPDFI GGLFERHYPN TKVFQLSCTF RFGHELSLMA NSVIRRNSTK
     LTKLCVSHPS TPKTEVRLHF DNCLSKVLSN LSVSSGTQAI LSRTKANLAE AEIALRLCGL
     PYRYLNGSSA LHTRTEIGIL VVGVLLSVYG DLRLLENHPN KQAIVYGFLK EAGFRWQKGQ
     FKAALSGLMA PHADLWSALG QLFEGAQYQK DRLGRLATIC QKDGEETPAI DVLRRLSMEG
     FIDSVGSEGV TRTGSNDQQR GVVRIGELLD SSKIDSRTFL NLILNPGEAA TDCDPFILST
     LHGSKGLEWD NVILIGLNEQ EFPGGKPDDV YSVRTSMNTP PAEEEIEEER RLFYVGITRT
     KQQLNLVVPL DEGLARWLKN RWDSTPKKSP IATRFVYEAG WTACAVTSDA IYNSTVEKQK
     ADFSKFHQWY LRDLQRLKV
//