ID Q6N095_HUMAN Unreviewed; 475 AA.
AC Q6N095;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN Name=DKFZp686K03196 {ECO:0000313|EMBL:CAE45775.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAE45775.1};
RN [1] {ECO:0000313|EMBL:CAE45775.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Esophagus tumor {ECO:0000313|EMBL:CAE45775.1};
RG The German cDNA Consortium;
RA Bahr A., Lauber J., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G.,
RA Han M., Wiemann S.;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:2NXY}
RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 55-246, AND DISULFIDE BONDS.
RX PubMed=17301785; DOI=10.1038/nature05580;
RA Zhou T., Xu L., Dey B., Hessell A.J., Van Ryk D., Xiang S.H., Yang X.,
RA Zhang M.Y., Zwick M.B., Arthos J., Burton D.R., Dimitrov D.S., Sodroski J.,
RA Wyatt R., Nabel G.J., Kwong P.D.;
RT "Structural definition of a conserved neutralization epitope on HIV-1
RT gp120.";
RL Nature 445:732-737(2007).
RN [3] {ECO:0007829|PDB:6V8X}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS) OF 20-248, AND DISULFIDE
RP BONDS.
RX PubMed=31980614; DOI=10.1038/s41467-019-14196-w;
RA Henderson R., Lu M., Zhou Y., Mu Z., Parks R., Han Q., Hsu A.L., Carter E.,
RA Blanchard S.C., Edwards R.J., Wiehe K., Saunders K.O., Borgnia M.J.,
RA Bartesaghi A., Mothes W., Haynes B.F., Acharya P., Munir Alam S.;
RT "Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced
RT rearrangements.";
RL Nat. Commun. 11:520-520(2020).
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DR EMBL; BX640621; CAE45775.1; -; mRNA.
DR PDB; 2NXY; X-ray; 2.00 A; D=20-246.
DR PDB; 6V8X; EM; 3.00 A; C/G/K=20-248.
DR PDBsum; 2NXY; -.
DR PDBsum; 6V8X; -.
DR AlphaFoldDB; Q6N095; -.
DR SMR; Q6N095; -.
DR IntAct; Q6N095; 2.
DR MaxQB; Q6N095; -.
DR EvolutionaryTrace; Q6N095; -.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd21817; IgC1_CH1_IgEG; 1.
DR CDD; cd07696; IgC1_CH3_IgAEM_CH2_IgG; 1.
DR CDD; cd05768; IgC1_CH3_IgAGD_CH4_IgAEM; 1.
DR CDD; cd04981; IgV_H; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR23411:SF39; IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED; 1.
DR PANTHER; PTHR23411; TAPASIN; 1.
DR Pfam; PF07654; C1-set; 3.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00407; IGc1; 3.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS00290; IG_MHC; 2.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2NXY, ECO:0007829|PDB:6V8X};
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunity {ECO:0000256|ARBA:ARBA00043265};
KW Immunoglobulin {ECO:0000256|ARBA:ARBA00043265};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022475}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..475
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004276917"
FT DOMAIN 15..116
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 151..244
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 266..365
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 374..470
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DISULFID 41..115
FT /evidence="ECO:0007829|PDB:2NXY, ECO:0007829|PDB:6V8X"
FT DISULFID 172..228
FT /evidence="ECO:0007829|PDB:2NXY, ECO:0007829|PDB:6V8X"
SQ SEQUENCE 475 AA; 52360 MW; 7BA14104CD2DB8F0 CRC64;
MDWTWRVFCL LAVAPGLHSQ VQLVQSGAEL KRPGASVTIS CRASGYSFST YHIHWVRQAP
GQRLEWMGIM NPRSDSKTYA QTFQGRMTMT RDTSTSTVFM ELNSLKSGDT AVYYCTRDRS
GRALWFGELD AFDIWGQGTK VTVSSASTKG PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE
PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL SSVVTVPSSS LGTQTYICNV NHKPSNTKVD
KKVEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE
VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI
EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWV SNGQPENNYK
TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEGL HNHYTQKSLS LSPGK
//
