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Database: UniProt
Entry: Q6NLA3_DROME
LinkDB: Q6NLA3_DROME
Original site: Q6NLA3_DROME 
ID   Q6NLA3_DROME            Unreviewed;       852 AA.
AC   Q6NLA3;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   22-NOV-2017, entry version 104.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=Vha100-1 {ECO:0000313|EMBL:AAS93702.1,
GN   ECO:0000313|FlyBase:FBgn0028671};
GN   Synonyms=BcDNA:LD21248 {ECO:0000313|EMBL:ACZ95062.1}, Dmel\CG1709
GN   {ECO:0000313|EMBL:ACZ95062.1}, V0 {ECO:0000313|EMBL:ACZ95062.1}, V0a
GN   {ECO:0000313|EMBL:ACZ95062.1}, v0a1 {ECO:0000313|EMBL:ACZ95062.1},
GN   V100 {ECO:0000313|EMBL:ACZ95062.1}, v100
GN   {ECO:0000313|EMBL:ACZ95062.1}, vha {ECO:0000313|EMBL:ACZ95062.1},
GN   Vha100 {ECO:0000313|EMBL:ACZ95062.1}, vha100-1
GN   {ECO:0000313|EMBL:ACZ95062.1};
GN   ORFNames=CG1709 {ECO:0000313|EMBL:ACZ95062.1,
GN   ECO:0000313|FlyBase:FBgn0028671}, Dmel_CG1709
GN   {ECO:0000313|EMBL:ACZ95062.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAS93702.1};
RN   [1] {ECO:0000313|EMBL:ACZ95062.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:ACZ95062.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:ACZ95062.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:ACZ95062.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:ACZ95062.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAR99124.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley {ECO:0000313|EMBL:AAR99124.1};
RA   Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA   Park S., Wan K., Yu C., Rubin G.M., Celniker S.;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AAS93702.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley {ECO:0000313|EMBL:AAS93702.1};
RA   Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA   Park S., Wan K., Yu C., Rubin G.M., Celniker S.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:ACZ95062.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [9] {ECO:0000313|EMBL:ACZ95062.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
RA   Yu C., Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:ACZ95062.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:ACZ95062.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [12] {ECO:0000313|EMBL:ACZ95062.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [13] {ECO:0000313|EMBL:ACZ95062.1}
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; BT011466; AAR99124.1; -; mRNA.
DR   EMBL; BT012431; AAS93702.1; -; mRNA.
DR   EMBL; AE014297; ACZ95062.1; -; Genomic_DNA.
DR   EMBL; AE014297; ACZ95063.1; -; Genomic_DNA.
DR   RefSeq; NP_001163768.1; NM_001170297.1.
DR   RefSeq; NP_001163769.1; NM_001170298.2.
DR   UniGene; Dm.16340; -.
DR   EnsemblMetazoa; FBtr0301650; FBpp0290864; FBgn0028671.
DR   EnsemblMetazoa; FBtr0301651; FBpp0290865; FBgn0028671.
DR   GeneID; 43442; -.
DR   KEGG; dme:Dmel_CG1709; -.
DR   CTD; 43442; -.
DR   FlyBase; FBgn0028671; Vha100-1.
DR   GeneTree; ENSGT00390000004941; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Reactome; R-DME-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-DME-6798695; Neutrophil degranulation.
DR   Reactome; R-DME-77387; Insulin receptor recycling.
DR   Reactome; R-DME-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-DME-983712; Ion channel transport.
DR   GenomeRNAi; 43442; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0028671; -.
DR   GO; GO:0005769; C:early endosome; IDA:FlyBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR   GO; GO:0045202; C:synapse; IDA:FlyBase.
DR   GO; GO:0008021; C:synaptic vesicle; IDA:FlyBase.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; ISS:FlyBase.
DR   GO; GO:0005516; F:calmodulin binding; IDA:FlyBase.
DR   GO; GO:0009881; F:photoreceptor activity; IMP:FlyBase.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; ISS:FlyBase.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; ISS:FlyBase.
DR   GO; GO:0097352; P:autophagosome maturation; IMP:FlyBase.
DR   GO; GO:0048749; P:compound eye development; IMP:FlyBase.
DR   GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:FlyBase.
DR   GO; GO:0051452; P:intracellular pH reduction; IMP:FlyBase.
DR   GO; GO:0009416; P:response to light stimulus; IMP:FlyBase.
DR   GO; GO:0007430; P:terminal branching, open tracheal system; IMP:FlyBase.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Hydrolase {ECO:0000313|EMBL:ACZ95062.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q6NLA3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    416    444       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    464    484       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    553    571       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    586    606       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    657    676       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    753    776       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    782    805       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   852 AA;  96831 MW;  AC4AD061069FE9BB CRC64;
     MGSLFRSEEM ALCQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRYLEK EIKKDGIPML DTGESPEAPQ PREMIDLEAT FEKLENELRE VNQNAEALKR
     NFLELTELKH ILRKTQVFFD EQEGGVNQTT ESMTRALITD EARTAGASMG PVQLGYMEKS
     NEREDYLPCF VAGVILRERL PAFERMLWRA CRGNVFLRQA MIETPLEDPT NGDQVHKSVF
     IIFFQGDQLK TRVKKICEGF RATLYPCPEA PADRREMAMG VMTRIEDLNT VLGQTQDHRH
     RVLVAAAKNL KNWFVKVRKI KAIYHTLNLF NLDVTQKCLI AECWVPLLDI ETIQLALRRG
     TERSGSSVPP ILNRMQTFEN PPTYNRTNKF TKAFQALIDA YGVASYREMN PAPYTIITFP
     FLFAVMFGDL GHGAIMALFG LWMIRKEKGL AAQKTDNEIW NIFFGGRYII FLMGVFSMYT
     GLIYNDIFSK SLNIFGSHWH LSYNKSTVME NKFLQLSPKG DYEGAPYPFG MDPIWQVAGA
     NKIIFHNAYK MKISIIFGVI HMIFGVVMSW HNHTYFRNRI SLLYEFIPQL VFLLLLFFYM
     VLLMFIKWIK FAATNDKPYS EACAPSILIT FIDMVLFNTP KPPPENCETY MFMGQHFIQV
     LFVLVAVGCI PVMLLAKPLL IMQARKQANE EVQPIAGATS DAEAGGVSNS GSHGGGGGHE
     EEEELSEIFI HQSIHTIEYV LGSVSHTASY LRLWALSLAH AQLAEVLWTM VLSIGLKQEG
     PVGGIVLTCV FAFWAILTVG ILVLMEGLSA FLHTLRLHWV EFQSKFYKGQ GYAFQPFSFD
     AIIENGAAAA EE
//
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