ID Q6NRB1_XENLA Unreviewed; 540 AA.
AC Q6NRB1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE Flags: Fragment;
GN Name=trim25l.L {ECO:0000313|Xenbase:XB-GENE-6251559};
GN Synonyms=LOC431932 {ECO:0000313|EMBL:AAH70851.1}, trim25l100490741
GN {ECO:0000313|Xenbase:XB-GENE-6251559}, trim25l100490741.L
GN {ECO:0000313|Xenbase:XB-GENE-6251559};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH70851.1};
RN [1] {ECO:0000313|EMBL:AAH70851.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocytes {ECO:0000313|EMBL:AAH70851.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR EMBL; BC070851; AAH70851.1; -; mRNA.
DR RefSeq; NP_001084882.2; NM_001091413.2.
DR AlphaFoldDB; Q6NRB1; -.
DR DNASU; 431932; -.
DR GeneID; 431932; -.
DR KEGG; xla:431932; -.
DR AGR; Xenbase:XB-GENE-6251559; -.
DR CTD; 431932; -.
DR Xenbase; XB-GENE-6251559; trim25l.L.
DR OrthoDB; 2939962at2759; -.
DR Bgee; 431932; Expressed in egg cell and 18 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR CDD; cd16597; RING-HC_TRIM25_C-IV; 1.
DR CDD; cd12891; SPRY_PRY_C-I_2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465:SF39; B BOX AND SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 25..69
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 149..190
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 347..540
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 248..297
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAH70851.1"
SQ SEQUENCE 540 AA; 60591 MW; 54D39898C67E6D5C CRC64;
GALCDSQTQK SVMAAAADLR DELNCSVCLT IYSDPVMLPC GHNFCQGCIV QVLDTQEATG
GVYTCPECRA QYMERPALQR NRTLGNIAER FFCAQPEPDG TGIFCTYCIH SPVPAAKSCL
LCEASLCESH VRVHSRSAEH VLTTPTAALE MRKCSVHREP LKYYCYVDSS CICASCCLAG
QHKRHRVELL SDASEKKKEK LRKVLLNLPL MIEEAERGGW RLQERRREVQ EQAAAETERV
VALFVDIRER LEALEQRVLR EVARQEEELS LQVSELIQQL EVKKEELSRK ILQTEELCNM
ADPLAVLQAG ESDRAEDDGG REGSDPKVLT VGDLDKDLIS ETLHSGLDSI VTVAKGWGVY
GKGATHIRLD IDTASNNVAV SEDRRTASWT SANQLRPQTP SRFIGYQVLS NNSFTSGQYF
WDMEVSESGS WRVGVAYPSI GRKGNQFWIG NNIKSWCLWR WNNGYSVRHD SHGTDLPQVP
SCTRIRISLD YQAGRLSFYE LGEPITHLHT FTASFTEPLH AAFWVWKDTL RGHSLVKVIS
//
