ID Q6NRF8_XENLA Unreviewed; 1049 AA.
AC Q6NRF8;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=DLC1 Rho GTPase activating protein S homeolog {ECO:0000313|RefSeq:NP_001084765.1};
DE SubName: Full=MGC83845 protein {ECO:0000313|EMBL:AAH70794.1};
GN Name=dlc1.S {ECO:0000313|RefSeq:NP_001084765.1,
GN ECO:0000313|Xenbase:XB-GENE-6251782};
GN Synonyms=dlc1 {ECO:0000313|RefSeq:NP_001084765.1,
GN ECO:0000313|Xenbase:XB-GENE-6251782}, MGC83845
GN {ECO:0000313|EMBL:AAH70794.1}, rhogap7
GN {ECO:0000313|RefSeq:NP_001084765.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH70794.1};
RN [1] {ECO:0000313|RefSeq:NP_001084765.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH70794.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocytes {ECO:0000313|EMBL:AAH70794.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001084765.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC070794; AAH70794.1; -; mRNA.
DR RefSeq; NP_001084765.1; NM_001091296.1.
DR DNASU; 431800; -.
DR GeneID; 431800; -.
DR KEGG; xla:431800; -.
DR AGR; Xenbase:XB-GENE-6251782; -.
DR CTD; 431800; -.
DR Xenbase; XB-GENE-6251782; dlc1.S.
DR OrthoDB; 2883046at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 431800; Expressed in lung and 18 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09591; SAM_DLC1; 1.
DR CDD; cd08869; START_RhoGAP; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF4; RHO-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 2: Evidence at transcript level;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 603..810
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 854..1024
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 146..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 118854 MW; 7C2ACF3CD2331304 CRC64;
MLVTQIEAKE ACDWLRAAGF PQYAQLYEDL QFPINIEIVK NDHEFLDRDA MESLYRRLNT
LNKCGAMKIE INRHRKRSDE SEEDEPCAIS NKWSYQRQSQ RWSRLENLEC PLPDEASSLS
LPIIPVLNIP KEDAAFSVLI DKNDASSLHS SSSGESDGSP KPYEELETSR SSSRCSSIKF
VSLDSTFSPS PCEMLNIISE EKLTDKPPNK KGKSLIRKME KLRIRSSTVK RNSYLKGKPT
ISGPVLLDGI DEDKLRNLNC VNISDLADAH SKAGFSCSSQ TCSSSSPSET SSTVSTPSPV
IRVRSHGKRG GIYAEDFDPN KLSLWNDISE RNFRNERHLH EQQIFQIPQG HKPGTFPKAL
TNSILSPMDN TSVNWRTGSF HGCNRNRMRS SSSKDTEMPS SPLSLVDNRL SIYDNVPNIP
FHFSKLESPG DDDDVFSELD NVMEHVNGLR KLVSEWSEKF SDDGDSDFAN DSVSPCPSSP
KTIHLEVNEH LDSKSKTDVR DAERCTPRTD SDSPILPYIT VSEIDSTFTD CSRQSPEPVN
LSMQVDSQSA AHLNRIQRLA LLKLTALMDK YSPSSKQGWN WNVPKFIRKI RAPDYKDKNV
FGVPFLLNVQ RTGHPIPKSI LQAMEYLRIH FLDQVGLFRK SGVKSRIQSL REMNEQDCKY
VNYEGQSAFD VADMVKQYFR DLPEPIFTSK LCESFLHIFQ YLPKDQQFRA VQAAILLLPD
ENRDALKILL YFLRDVVACV KENQMTPTNI AVCLAPSLFH LNTLRRESSS SSRSSQRKYS
LGKPDQKDLS ENLAATQGLA HMIAECNRLF QLPDYWCDLC PSICEVQPIH AETSVNTSTN
SLAAHCGTLV SLENSMQNLL RDAKDKYRSW VACSGFEHVE LAFKKVESDE FPIRVWKAST
EIEAKPHAVL QHILREQHTW DPNLQQSKII ETLDEDTEIY HYITESMPPL PCREYVVLRT
WRTDPQSGTC ILAATSVECE DVPISGILGH VILCQHLIEN IGTQKCKVTH SCRTDTRGRS
TEWYNKVCGH MCAAEILRIK DSFNKKKTP
//
