GenomeNet

Database: UniProt
Entry: Q6NRT3
LinkDB: Q6NRT3
Original site: Q6NRT3 
ID   SMU1_XENLA              Reviewed;         513 AA.
AC   Q6NRT3;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   22-NOV-2017, entry version 80.
DE   RecName: Full=WD40 repeat-containing protein SMU1;
DE   AltName: Full=Smu-1 suppressor of mec-8 and unc-52 protein homolog;
GN   Name=smu1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Auxiliary spliceosomal protein that regulates selection
CC       of alternative splice sites in a small set of target pre-mRNA
CC       species. Regulates alternative splicing of the hspg2 pre-mRNA.
CC       Required for normal mitotic spindle assembly and normal progress
CC       through mitosis. {ECO:0000250|UniProtKB:Q76B40}.
CC   -!- SUBUNIT: Interacts with ik. Probable component of the spliceosome
CC       B complex. {ECO:0000250|UniProtKB:Q2TAY7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99M63}.
CC       Nucleus {ECO:0000250|UniProtKB:Q76B40}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q76B40}. Note=Colocalizes with srsf1 in
CC       nuclear speckles. {ECO:0000250|UniProtKB:Q76B40}.
CC   -!- DOMAIN: The WD repeats assemble into a seven-bladed WD propeller.
CC       {ECO:0000250|UniProtKB:G5EEG7}.
CC   -!- SIMILARITY: Belongs to the WD repeat SMU1 family. {ECO:0000305}.
DR   EMBL; BC070636; AAH70636.1; -; mRNA.
DR   RefSeq; NP_001084865.1; NM_001091396.1.
DR   UniGene; Xl.7709; -.
DR   ProteinModelPortal; Q6NRT3; -.
DR   SMR; Q6NRT3; -.
DR   BioGrid; 101280; 1.
DR   IntAct; Q6NRT3; 3.
DR   MaxQB; Q6NRT3; -.
DR   GeneID; 431914; -.
DR   KEGG; xla:431914; -.
DR   CTD; 431914; -.
DR   Xenbase; XB-GENE-6251564; smu1.
DR   HOVERGEN; HBG079573; -.
DR   KO; K13111; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00668; CTLH; 1.
DR   SMART; SM00667; LisH; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Repeat;
KW   Spliceosome; WD repeat.
FT   CHAIN         1    513       WD40 repeat-containing protein SMU1.
FT                                /FTId=PRO_0000237595.
FT   DOMAIN        6     38       LisH. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00126}.
FT   DOMAIN       40     92       CTLH. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00058}.
FT   REPEAT      212    253       WD 1. {ECO:0000255}.
FT   REPEAT      262    303       WD 2. {ECO:0000255}.
FT   REPEAT      305    346       WD 3. {ECO:0000255}.
FT   REPEAT      347    386       WD 4. {ECO:0000255}.
FT   REPEAT      395    436       WD 5. {ECO:0000255}.
FT   REPEAT      440    479       WD 6. {ECO:0000255}.
FT   REPEAT      482    513       WD 7. {ECO:0000255}.
FT   REGION        1    315       Required for interaction with ik.
FT                                {ECO:0000250|UniProtKB:Q2TAY7}.
SQ   SEQUENCE   513 AA;  57623 MW;  C160DCA8BDD2E29F CRC64;
     MSIEIESSDV IRLIMQYLKE NSLHRTLATL QEETTVSLNT VDSIESFVAD INSGHWDTVL
     QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT DPMIMLKQNQ SERYIHLENL
     LARSYFDPRE AYPDGSSKEK RRTAIAQALA GEVSVVPPSR LMALLGQALK WQQHQGLLPP
     GMTIDLFRGK AAVKDVEEEK FPTQLSRHIK FGQKSHVECA RFSPDGQYLV TGSVDGFIEV
     WNFTTGKIRK DLKYQAQDNF MMMDDAVLCM CFSRDTEMLA TGAQDGKIKV WKIQSGQCLR
     RFERAHSKGV TCLSFSKDSS QILSASFDQT IRIHGLKSGK TLKEFRGHSS FVNEATFTQD
     GHYIISASSD GTVKIWNMKT TECSNTFKSL GSTAGTDITV NSVILLPKNP EHFVVCNRSN
     TVVIMNMQGQ IVRSFSSGKR EGGDFVCCTL SPRGEWIYCV GEDFVLYCFS TVTGKLERTL
     TVHEKDVIGI AHHPHQNLIG TYSEDGLLKL WKP
//
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