ID Q6NUW4_DANRE Unreviewed; 264 AA.
AC Q6NUW4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 {ECO:0000313|RefSeq:NP_998441.1};
DE EC=3.5.3.18 {ECO:0000313|RefSeq:NP_998441.1};
DE SubName: Full=Zgc:85829 {ECO:0000313|EMBL:AAH68404.1};
GN Name=ddah1 {ECO:0000313|RefSeq:NP_998441.1,
GN ECO:0000313|ZFIN:ZDB-GENE-010724-13};
GN Synonyms=fc30c11 {ECO:0000313|RefSeq:NP_998441.1}, wu:fc30c11
GN {ECO:0000313|RefSeq:NP_998441.1};
GN OrderedLocusNames=zgc:85829 {ECO:0000313|EMBL:AAH68404.1,
GN ECO:0000313|RefSeq:NP_998441.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH68404.1};
RN [1] {ECO:0000313|RefSeq:NP_998441.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11435403; DOI=10.1101/gr.186001;
RA Rajarao S.J., Canfield V.A., Mohideen M.A., Yan Y.L., Postlethwait J.H.,
RA Cheng K.C., Levenson R.;
RT "The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in
RT the zebrafish, Danio rerio.";
RL Genome Res. 11:1211-1220(2001).
RN [2] {ECO:0000313|EMBL:AAH68404.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH68404.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_998441.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [5] {ECO:0000313|RefSeq:NP_998441.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DDAH family.
CC {ECO:0000256|ARBA:ARBA00008532}.
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DR EMBL; BC068404; AAH68404.1; -; mRNA.
DR RefSeq; NP_998441.1; NM_213276.1.
DR DNASU; 406561; -.
DR GeneID; 406561; -.
DR KEGG; dre:406561; -.
DR AGR; ZFIN:ZDB-GENE-040426-2446; -.
DR CTD; 23576; -.
DR ZFIN; ZDB-GENE-010724-13; ddah1.
DR OrthoDB; 315054at2759; -.
DR PhylomeDB; Q6NUW4; -.
DR Proteomes; UP000000437; Chromosome 23.
DR GO; GO:0016403; F:dimethylargininase activity; IEA:UniProtKB-EC.
DR InterPro; IPR033199; DDAH-like.
DR PANTHER; PTHR12737; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE; 1.
DR PANTHER; PTHR12737:SF17; N(G),N(G)-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; 1.
DR Pfam; PF02274; ADI; 1.
DR SUPFAM; SSF55909; Pentein; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6NUW4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT ACT_SITE 156
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-1"
FT ACT_SITE 257
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-1"
FT BINDING 13
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT BINDING 56
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT BINDING 61..62
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT BINDING 81
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT BINDING 128
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT BINDING 251
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
SQ SEQUENCE 264 AA; 28608 MW; 804E4E0C5A91A7DF CRC64;
MRAMPASLST AALRSDNVSP VDPLGVQREF DHYVSVLRDR LGLQVVMLPA DEELPDCVFV
EDTAVVCGST ALITRPGAPS RRSETVAMKG ALTELGLNIV EMNDESATMD GGDVLFTGKE
FFVGLSKRTN QRGAEILANT FKDYAVSTIP VEEGLHLKSF CSMAGPNLIA IGSSDAAQKA
LKVIQQMSDC KYEKLTVPDD RAANCVYMNL PGKGDVLLHC TPEVFPESAK VFERLKSHML
IPVSNQEKMK VDGALTCLSV LLRI
//
