ID Q6P2U4_DANRE Unreviewed; 287 AA.
AC Q6P2U4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=sult2st1 {ECO:0000313|EMBL:AAH64294.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030219-114};
GN Synonyms=id:ibd1140 {ECO:0000313|RefSeq:NP_944596.2}, sult2st
GN {ECO:0000313|RefSeq:NP_944596.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH64294.1};
RN [1] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11731487;
RA Kudoh T., Tsang M., Hukriede N.A., Chen X., Dedekian M., Clarke C.J.,
RA Kiang A., Schultz S., Epstein J.A., Toyama R., Dawid I.B.;
RT "A gene expression screen in zebrafish embryogenesis.";
RL Genome Res. 11:1979-1987(2001).
RN [2] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12885295;
RA Sugahara T., Yang Y.S., Liu C.C., Pai T.G., Liu M.C.;
RT "Sulphonation of dehydroepiandrosterone and neurosteroids: molecular
RT cloning, expression, and functional characterization of a novel zebrafish
RT SULT2 cytosolic sulphotransferase.";
RL Biochem. J. 375:785-791(2003).
RN [3] {ECO:0000313|EMBL:AAH64294.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAH64294.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14726148;
RA Ohkimoto K., Liu M.Y., Suiko M., Sakakibara Y., Liu M.C.;
RT "Characterization of a zebrafish estrogen-sulfating cytosolic
RT sulfotransferase: inhibitory effects and mechanism of action of
RT phytoestrogens.";
RL Chem. Biol. Interact. 147:1-7(2004).
RN [5] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17045951; DOI=10.1016/j.abb.2006.09.004;
RA Yasuda S., Liu M.Y., Yang Y.S., Snow R., Takahashi S., Liu M.C.;
RT "Identification of novel hydroxysteroid-sulfating cytosolic SULTs, SULT2
RT ST2 and SULT2 ST3, from zebrafish: cloning, expression, characterization,
RT and developmental expression.";
RL Arch. Biochem. Biophys. 455:1-9(2006).
RN [6] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18339436;
RA Hoffmann J.L., Thomason R.G., Lee D.M., Brill J.L., Price B.B., Carr G.J.,
RA Versteeg D.J.;
RT "Hepatic gene expression profiling using GeneChips in zebrafish exposed to
RT 17alpha-methyldihydrotestosterone.";
RL Aquat. Toxicol. 87:69-80(2008).
RN [7] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23072875;
RA Cannon J.E., Place E.S., Eve A.M., Bradshaw C.R., Sesay A., Morrell N.W.,
RA Smith J.C.;
RT "Global analysis of the haematopoietic and endothelial transcriptome during
RT zebrafish development.";
RL Mech. Dev. 130:122-131(2013).
RN [8] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23598338; DOI=10.1038/nature12027;
RA Amemiya C.T., Alfoldi J., Lee A.P., Fan S., Philippe H., Maccallum I.,
RA Braasch I., Manousaki T., Schneider I., Rohner N., Organ C., Chalopin D.,
RA Smith J.J., Robinson M., Dorrington R.A., Gerdol M., Aken B.,
RA Biscotti M.A., Barucca M., Baurain D., Berlin A.M., Blatch G.L.,
RA Buonocore F., Burmester T., Campbell M.S., Canapa A., Cannon J.P.,
RA Christoffels A., De Moro G., Edkins A.L., Fan L., Fausto A.M., Feiner N.,
RA Forconi M., Gamieldien J., Gnerre S., Gnirke A., Goldstone J.V., Haerty W.,
RA Hahn M.E., Hesse U., Hoffmann S., Johnson J., Karchner S.I., Kuraku S.,
RA Lara M., Levin J.Z., Litman G.W., Mauceli E., Miyake T., Mueller M.G.,
RA Nelson D.R., Nitsche A., Olmo E., Ota T., Pallavicini A., Panji S.,
RA Picone B., Ponting C.P., Prohaska S.J., Przybylski D., Saha N.R., Ravi V.,
RA Ribeiro F.J., Sauka-Spengler T., Scapigliati G., Searle S.M., Sharpe T.,
RA Simakov O., Stadler P.F., Stegeman J.J., Sumiyama K., Tabbaa D., Tafer H.,
RA Turner-Maier J., van Heusden P., White S., Williams L., Yandell M.,
RA Brinkmann H., Volff J.N., Tabin C.J., Shubin N., Schartl M., Jaffe D.B.,
RA Postlethwait J.H., Venkatesh B., Di Palma F., Lander E.S., Meyer A.,
RA Lindblad-Toh K.;
RT "The African coelacanth genome provides insights into tetrapod evolution.";
RL Nature 496:311-316(2013).
RN [9] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [10] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [11] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [12] {ECO:0000313|RefSeq:NP_944596.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28807679;
RA Kurogi K., Yoshihama M., Horton A., Schiefer I.T., Krasowski M.D.,
RA Hagey L.R., Williams F.E., Sakakibara Y., Kenmochi N., Suiko M., Liu M.C.;
RT "Identification and characterization of 5alpha-cyprinol-sulfating cytosolic
RT sulfotransferases (Sults) in the zebrafish (Danio rerio).";
RL J. Steroid Biochem. Mol. Biol. 174:120-127(2017).
RN [13] {ECO:0000313|RefSeq:NP_944596.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|ARBA:ARBA00005771, ECO:0000256|RuleBase:RU361155}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC064294; AAH64294.1; -; mRNA.
DR RefSeq; NP_944596.2; NM_198914.2.
DR GeneID; 338214; -.
DR KEGG; dre:338214; -.
DR AGR; ZFIN:ZDB-GENE-030219-114; -.
DR CTD; 338214; -.
DR ZFIN; ZDB-GENE-030219-114; sult2st1.
DR OrthoDB; 3083090at2759; -.
DR Proteomes; UP000000437; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008146; F:sulfotransferase activity; IDA:ZFIN.
DR GO; GO:0016783; F:sulfurtransferase activity; IDA:ZFIN.
DR GO; GO:0051923; P:sulfation; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR11783:SF64; SULFOTRANSFERASE; 1.
DR PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6P2U4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 35..280
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
SQ SEQUENCE 287 AA; 33601 MW; C2999111765786F0 CRC64;
MTEAELYSSY KGVLVPSYVH PAESLKYYED FTFRPDDILI ITFPKSGTTW MQEIVPLVVS
EGDLTPVLTV PNWDRVPWLE EHRAILLSLE QRASPRIFAT HFHHQMMNPS YFKIKPRVLY
VMRNPKDVFI SSYHFHEMAS FLVSPGTQDE FLEKFLDGTI MFGSWFDHVK SWLNAGEQEH
ILYLCYEDMI SDLKASVDKI ATFLGKSLSS EVVEKIADHC VFKNMKQNKM SNYSLVPEEF
MDQKKSEFLR KGIVGDWKNH FSTAQEQKFN AVYQEKMKDV KFSFPWD
//
