ID Q6P3G9_DANRE Unreviewed; 408 AA.
AC Q6P3G9; A0A8M1PI56;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE SubName: Full=Endoplasmic reticulum protein 44 {ECO:0000313|Ensembl:ENSDARP00000017258};
DE SubName: Full=Endoplasmic reticulum resident protein 44 {ECO:0000313|RefSeq:NP_957186.1};
DE SubName: Full=Thioredoxin domain containing 4 (Endoplasmic reticulum) {ECO:0000313|EMBL:AAH63992.1};
GN Name=erp44 {ECO:0000313|Ensembl:ENSDARP00000017258,
GN ECO:0000313|RefSeq:NP_957186.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1902};
GN Synonyms=txndc4 {ECO:0000313|EMBL:AAH63992.1,
GN ECO:0000313|RefSeq:NP_957186.1}, zgc:77883
GN {ECO:0000313|RefSeq:NP_957186.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH63992.1};
RN [1] {ECO:0000313|EMBL:AAH63992.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAH63992.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_957186.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23014190;
RA Cuello S., Ximenez-Embun P., Ruppen I., Schonthaler H.B., Ashman K.,
RA Madrid Y., Luque-Garcia J.L., Camara C.;
RT "Analysis of protein expression in developmental toxicity induced by MeHg
RT in zebrafish.";
RL Analyst 137:5302-5311(2012).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000017258}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000017258};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000017258, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000017258};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_957186.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25332179; DOI=10.1161/jaha.114.001018;
RA Wang D.Y., Abbasi C., El-Rass S., Li J.Y., Dawood F., Naito K., Sharma P.,
RA Bousette N., Singh S., Backx P.H., Cox B., Wen X.Y., Liu P.P.,
RA Gramolini A.O.;
RT "Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and
RT zebrafish leads to cardiac developmental and functional defects.";
RL J. Am. Heart Assoc. 3:e001018-e001018(2014).
RN [6] {ECO:0000313|RefSeq:NP_957186.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25975375;
RA Long Y., Yan J., Song G., Li X., Li X., Li Q., Cui Z.;
RT "Transcriptional events co-regulated by hypoxia and cold stresses in
RT Zebrafish larvae.";
RL BMC Genomics 16:385-385(2015).
RN [7] {ECO:0000313|RefSeq:NP_957186.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_957186.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [9] {ECO:0000313|RefSeq:NP_957186.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [10] {ECO:0000313|RefSeq:NP_957186.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR848817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063992; AAH63992.1; -; mRNA.
DR RefSeq; NP_957186.1; NM_200892.1.
DR STRING; 7955.ENSDARP00000017258; -.
DR PaxDb; 7955-ENSDARP00000017258; -.
DR Ensembl; ENSDART00000027545.9; ENSDARP00000017258.8; ENSDARG00000019008.11.
DR GeneID; 393866; -.
DR KEGG; dre:393866; -.
DR AGR; ZFIN:ZDB-GENE-040426-1902; -.
DR CTD; 23071; -.
DR ZFIN; ZDB-GENE-040426-1902; erp44.
DR eggNOG; KOG0912; Eukaryota.
DR OMA; DWCRFSN; -.
DR OrthoDB; 90290at2759; -.
DR TreeFam; TF106378; -.
DR Reactome; R-DRE-6798695; Neutrophil degranulation.
DR Proteomes; UP000000437; Chromosome 16.
DR Bgee; ENSDARG00000019008; Expressed in granulocyte and 29 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; IMP:ZFIN.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IMP:ZFIN.
DR CDD; cd02996; PDI_a_ERp44; 1.
DR CDD; cd03072; PDI_b'_ERp44; 1.
DR CDD; cd03070; PDI_b_ERp44; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR InterPro; IPR041862; ERp44_PDI_b.
DR InterPro; IPR041870; ERp44_PDI_b.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46295; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44; 1.
DR PANTHER; PTHR46295:SF1; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 3.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6P3G9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 6..141
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 358..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 408 AA; 46987 MW; 85A1D6D5279C52E7 CRC64;
MKLSSIIPVP ELHYFTLLLV TGLYNPGRGE ITSLDSGNID DILNGAGVAL VNFYADWCRF
SQMLHPIFEE ASNIVREEYP DATQVVFGRV DCDQHSDLAQ RYRISKYPTL KLFRNGMMMK
REYRGQRSVT AIADFIRQQK VDPIKEIENL EEISTVDRSR RTIIGYFEKR DSDNYRTYEK
VANILRDDCA FLAAFGEVSK PERFSGDNII YKPLGENAPD MVYMGSLTNF DLSYAWTQDK
CVPLVREITF ENGEELTEEG IPFLILFHQK DDTESLEKFQ QEVARQLISE KGSINFLHAD
CDKFRHPLLH IQKTPADCPV IAIDSFRHMY VFPEFSDLAV PGKLRQFVLD LHSGKLHREF
HHGPDPTDST PGQQEENREV PSNPPESSFQ KLAPSETRYT ILRDRDEL
//
